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Drug Information

Drug Information for TRIAMTERENE/HYDROCHLOROTHIAZIDECAPSULES, USP37.5 MG/25 MG (BARR LABORATORIES, INC.): DESCRIPTION

Triamterene is an antikaliuretic agent and hydrochlorothiazide is a diuretic/antihypertensive agent.
At 50°C, triamterene is practically insoluble in water (less than 0.1%). It is soluble in formic acid, sparingly soluble in methoxyethanol and very slightly soluble in alcohol.
Triamterene is 2,4,7-triamino-6-phenylpteridine and its structural formula is:
Hydrochlorothiazide is slightly soluble in water. It is soluble in dilute ammonia, dilute aqueous sodium hydroxide and dimethylformamide. It is sparingly soluble in methanol.
Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7- sulfonamide 1,1-dioxide and its structural formula is:
Each capsule, for oral administration, contains 37.5 mg triamterene and 25 mg hydrochlorothiazide. In addition, inactive ingredients include cetylpyridinium chloride, gelatin, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polysorbate 80, pregelatinized starch, sodium starch glycolate and titanium dioxide.
This product complies with USP Dissolution Test 3.

Drug Information Provided by National Library of Medicine (NLM).

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