Drug Information for TOBRAMYCININJECTION, USP (Hospira, Inc.): DESCRIPTION

  • Tobramycin Sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived from the actinomycete Streptomyces tenebrarius. Tobramycin Injection, USP is a clear and colorless sterile aqueous solution for parenteral administration.

    Each mL contains tobramycin sulfate equivalent to 10 mg (pediatric) or 40 mg tobramycin; sodium metabisulfite added as an antioxidant 3 mg; and edetate disodium added as a stabilizer, 0.1 mg. Contains sulfuric acid and may contain sodium hydroxide for pH adjustment. pH 4.0 (3.0 to 6.5).

    Tobramycin sulfate is O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-L-streptamine sulfate (2:5)(salt) and has the chemical formula (C18H37N5O9)2 • 5H2SO4. The molecular weight is 1,425.45. The structural formula for tobramycin is as follows:

  • Drug Information Provided by National Library of Medicine (NLM).