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Drug Information for TAZORAC (tazarotene) Gel 0.05%(tazarotene) Gel 0.1% (Allergan, Inc.): ADVERSE REACTIONS
- CLINICAL PHARMACOLOGY
- INDICATIONS AND USAGE
- ADVERSE REACTIONS
- HOW SUPPLIED
- Diseases/Conditions Related to TAZORAC (tazarotene) Gel 0.05%(tazarotene) Gel 0.1% (Allergan, Inc.)
- External Links Related to TAZORAC (tazarotene) Gel 0.05%(tazarotene) Gel 0.1% (Allergan, Inc.)
In human dermal safety studies, tazarotene 0.05% and 0.1% gels did not induce allergic contact sensitization, phototoxicity or photoallergy.
The most frequent adverse events reported with TAZORAC® Gel 0.05% and 0.1% were limited to the skin. Those occurring in 10 to 30% of patients, in descending order, included pruritus, burning/stinging, erythema, worsening of psoriasis, irritation, and skin pain. Events occurring in 1 to 10% of patients included rash, desquamation, irritant contact dermatitis, skin inflammation, fissuring, bleeding and dry skin. Increases in “psoriasis worsening” and “sun-induced erythema” were noted in some patients over the 4th to 12th months as compared to the first three months of a 1 year study. In general, the incidence of adverse events with TAZORAC® Gel 0.05% was 2 to 5% lower than that seen with TAZORAC® Gel 0.1%.
The most frequent adverse events reported with TAZORAC® Gel 0.1% in the treatment of acne occurring in 10 to 30% of patients, in descending order, included desquamation, burning/stinging, dry skin, erythema and pruritus. Events occurring in 1 to 10% of patients included irritation, skin pain, fissuring, localized edema and skin discoloration.
- Drug Information Provided by National Library of Medicine (NLM).