- Differential Diagnosis
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Drug Information for Pharmalgen (ALK-Abello A S): WARNING
- Clinical Pharmacology 1
- Indications and Usage
- Adverse Reactions
- Dosage and Administration
- How Supplied
- PRINCIPAL DISPLAY PANEL
- External Links Related to Pharmalgen (ALK-Abello A S)
Hymenoptera venom preparations should be used only by or under the direction of physicians experienced in administering allergens to the maximum tolerated dose and only where adequate means for treating severe systemic reactions are immediately available.
Allergenic extracts may potentially elicit a severe life-threatening systemic reaction, rarely resulting in death1. Because of the possibility of severe systemic reactions, the patient should be instructed in the recognition of anaphylactic symptoms, observed in the office for at least 30 minutes after each injection, and warned to return to the office if symptoms of an allergic reaction occur.
Patients receiving beta-blockers may not be responsive to epinephrine or inhaled bronchodilators, and the risk of severely complicating the treatment of systemic reactions should be carefully considered before a decision to treat is reached.
Treatment with ACE-inhibitors should be stopped at least 24 hours prior to injection due to an increased risk of anaphylactic reaction based on inhibition of the angiotensin metabolism.
All patients receiving venom immunotherapy should be instructed in the procedure for emergency self-injection of subcutaneous epinephrine. This self treatment might be necessary before patients have reached a maintenance dose of venom, and partially treated patients should be advised to carry an emergency epinephrine kit during the Hymenoptera season.
Before administering these venom preparations, physicians should be thoroughly familiar with the information in this insert, especially the Warnings, Precautions, and Adverse Reactions sections.
- Drug Information Provided by National Library of Medicine (NLM).