Drug Information for Pharmalgen (ALK-Abello A S): Description

  • Six sterile freeze-dried Hymenoptera preparations are available: honey bee venom, and yellow jacket, yellow hornet, white faced (bald faced) hornet, wasp, and mixed vespid venom protein. The mixed vespid preparation consists of equal amounts of yellow jacket, yellow hornet, and white-faced hornet venom proteins.

    Honey bees, yellow hornets, and white faced hornets are present primarily as the single species designated above, and the source material for those extracts is collected only from those species. There are a number of common species of yellow jackets and wasps in the environment, and those extracts reflect that variety and contain venom protein from a number of species. Information concerning the species included in the yellow jacket and wasp preparations is available on request from ALK customer service (1-800-252-9778); in TX and Canada, 1-800-663-0972).

    Honey bee venom is obtained from live insects by an electric shock method. The other venoms are obtained from dissected venom sacs, which are crushed in a ß-alanine/acetic acid buffer to release the venom. The sac residue is then removed by centrifugation and filtration. Allergenic components in the raw honey bee and yellow jacket venom materials have been described2, 3.

    These extracts are available in freeze-dried form, and just prior to use, the contents of each vial should be reconstituted with HSA diluent (see How Supplied), using the volume specified on the vial label. When reconstituted as directed, the single-venom preparations will contain 100 µg/ml of venom or venom protein, and the mixed vespid preparation will contain 300 µg/ml of venom protein. This is the concentration from which full maintenance doses are typically drawn. Other ingredients in the solution reconstituted as directed with HSA diluent are 0.06% albumin human USP, 3.0% mannitol, 0.9% sodium chloride, and 0.4% phenol. All these preparations must be diluted before use in diagnosis or in the initial stages of treatment.

  • Drug Information Provided by National Library of Medicine (NLM).