Drug Information for Pharmalgen (ALK-Abello A S): Clinical Pharmacology 1

Ads
  • The mode of action of allergenic extracts is under investigation.

    The skin test reaction occurring in previously sensitized individuals is probably related to the interaction of antigen with IgE antibody and the subsequent release of histamine from mast cells. The therapeutic action of allergenic extracts may be related to the production of IgG (blocking) antibodies. Effective immunotherapy with allergenic extracts is usually associated with a rise in serum levels of specific IgG. Immunotherapy also produces an initial rise in specific IgE levels, which then decrease as therapy continues.

    The skin test reaction occurring in previously sensitized individuals is probably related to the interaction of antigen with IgE antibody and the subsequent release of histamine from mast cells. The therapeutic action of allergenic extracts may be related to the production of IgG (blocking) antibodies. Effective immunotherapy with allergenic extracts is usually associated with a rise in serum levels of specific IgG. Immunotherapy also produces an initial rise in specific IgE levels, which then decrease as therapy continues.

  • Drug Information Provided by National Library of Medicine (NLM).
Ads