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Drug Information for Paclitaxel Injection (Teva Parenteral Medicines, Inc): WARNING
- CLINICAL PHARMACOLOGY
- INDICATIONS AND USAGE
- DOSAGE AND ADMINISTRATION
- HOW SUPPLIED
- Patient Information
- PRINCIPAL DISPLAY PANEL - 5 mL Carton
- PRINCIPAL DISPLAY PANEL - 16.7 mL Carton
- PRINCIPAL DISPLAY PANEL - 25 mL Carton
- PRINCIPAL DISPLAY PANEL - 50 mL Carton
- External Links Related to Paclitaxel Injection (Teva Parenteral Medicines, Inc)
Paclitaxel injection should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available.
Anaphylaxis and severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in 2 to 4% of patients receiving paclitaxel in clinical trials. Fatal reactions have occurred in patients despite premedication. All patients should be pretreated with corticosteroids, diphenhydramine, and H2 antagonists. (See DOSAGE AND ADMINISTRATION.) Patients who experience severe hypersensitivity reactions to paclitaxel injection should not be rechallenged with the drug.
Paclitaxel injection therapy should not be given to patients with solid tumors who have baseline neutrophil counts of less than 1500 cells/mm3 and should not be given to patients with AIDS-related Kaposi's sarcoma if the baseline neutrophil count is less than 1000 cells/mm3. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving paclitaxel injection.
- Drug Information Provided by National Library of Medicine (NLM).