- Differential Diagnosis
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Drug Information for ONDANSETRON Oral Solution, USP (Roxane Laboratories, Inc): OVERDOSAGE
- INDICATIONS AND USAGE
- ADVERSE REACTIONS
- DRUG ABUSE AND DEPENDENCE
- HOW SUPPLIED
- Package Label - Ondansetron Oral Solution, USP
- External Links Related to ONDANSETRON Oral Solution, USP (Roxane Laboratories, Inc)
There is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy. Individual intravenous doses as large as 150 mg and total daily intravenous doses as large as 252 mg have been inadvertently administered without significant adverse events. These doses are more than 10 times the recommended daily dose.
In addition to the adverse events listed above, the following events have been described in the setting of ondansetron overdose: “Sudden blindness” (amaurosis) of 2 to 3 minutes’ duration plus severe constipation occurred in 1 patient that was administered 72 mg of ondansetron intravenously as a single dose. Hypotension (and faintness) occurred in a patient that took 48 mg of ondansetron tablets. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed. In all instances, the events resolved completely.
- Drug Information Provided by National Library of Medicine (NLM).