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Drug Information

Drug Information for OLUX (clobetasol propionate) Foam, 0.05% (Connetics Corporation): DESCRIPTION

OLUX Foam contains clobetasol propionate, USP, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.
Clobetasol propionate is pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-, with the empirical formula C₂₅H₃₂CIF0₅, a molecular weight of 466.97. The following is the chemical structure:
Clobetasol propionate is a white or almost white, odorless, crystalline powder and is insoluble in water.
OLUX® (clobetasol propionate) Foam, 0.05%, contains 0.5 mg clobetasol propionate, USP, per gram in a thermolabile hydroethanolic foam vehicle consisting of cetyl alcohol, citric acid, ethanol (60%), polysorbate 60, potassium citrate, propylene glycol, purified water, and stearyl alcohol pressurized with a hydrocarbon (propane/butane) propellant.

Drug Information Provided by National Library of Medicine (NLM).

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