Drug Information for Junel ™ 21 Day (norethindrone acetate and ethinyl estradiol tablets, USP) Junel ™ Fe28 Day (norethindrone acetate and ethinyl estradiol tablets, USP and ferrous fumarate tablets*)*Ferrous fumarate tablets are not USP for dissolution and assay. (BARR LABORATORIES, INC.): NON-CONTRACEPTIVE HEALTH BENEFITS

  • The following non-contraceptive health benefits related to the use of oral contraceptives are supported by epidemiological studies which largely utilized oral contraceptive formulations containing estrogen doses exceeding 0.035 mg of ethinyl estradiol or 0.05 mg of mestranol (79-84).

    Effects on menses:

    • Increased menstrual cycle regularity
    • Decreased blood loss and decreased incidence of iron deficiency anemia
    • Decreased incidence of dysmenorrhea

    Effects related to inhibition of ovulation:

    • Decreased incidence of functional ovarian cysts
    • Decreased incidence of ectopic pregnancies

    Effects from long-term use:

    • Decreased incidence of fibroadenomas and fibrocystic disease of the breast
    • Decreased incidence of acute pelvic inflammatory disease
    • Decreased incidence of endometrial cancer
    • Decreased incidence of ovarian cancer
  • Drug Information Provided by National Library of Medicine (NLM).