Drug Information for FANSIDAR brand ofsulfadoxine and pyrimethamineTABLETS (Roche Pharmaceuticals): DOSAGE AND ADMINISTRATION

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  • (See INDICATIONS AND USAGE)

    The dosage should be swallowed whole, and not chewed, with plenty of fluids after a meal.

  • Treatment of Acute Malaria

  • Adults2 to 3 tablets taken as a single dose.
    Pediatric patients(>2 months to 18 years)The dosage for treatment of malaria in children is based upon body weight:
    Weight (kg)Number of Tablets Takenas a Single Dose
    >453
    31 to 452
    21 to 301 ½
    11 to 201
    5 to 10½
  • Prevention of Malaria

  • The malaria risk must be carefully weighed against the risk of serious adverse drug reactions (see INDICATIONS AND USAGE). If Fansidar is prescribed for prophylaxis, it is important that the physician inquires about sulfonamide intolerance and points out the risk and the need for immediate drug withdrawal if skin reactions do occur.

    The first dose of Fansidar should be taken 1 or 2 days before arrival in an endemic area; administration should be continued during the stay and for 4 to 6 weeks after return.

    Once WeeklyOnce Every 2 Weeks
    Adults1 tablet2 tablets
    Pediatric patients(>2 months to 18 years)The dosage for prevention of malaria in children is based upon body weight:
    Weight (kg)Number of Tablets TakenOnce Weekly
    >451 ½
    31 to 451
    21 to 30¾
    11 to 20½
    5 to 10¼

    Prophylaxis with Fansidar should not be continued for more than two years, since no experience of more prolonged administration is available to date.

  • Drug Information Provided by National Library of Medicine (NLM).
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