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Drug Information

Drug Information for CLARITHROMYCIN (KAISER FOUNDATION HOSPITALS): DESCRIPTION

Clarithromycin is a semi-synthetic macrolide antibiotic. Chemically, it is 6-0-methylerythromycin. The molecular formula is C₃₈H₆₉NO₁₃, and the molecular weight is 747.96. The structural formula is:
Clarithromycin is a white to off-white crystalline powder. It is soluble in acetone, slightly soluble inmethanol, ethanol, and acetonitrile, and practically insoluble in water.Clarithromycin is available as immediate-release tablets, extended-release tablets, and granules for oral suspension.Each yellow oval film-coated immediate-release tablet of Clarithromycin Tablets, USP contains 250mg or 500mg of clarithromycin and the following inactive ingredients:250mg tablets: hypromellose, hydroxypropyl cellulose, croscarmellose sodium, D and C Yellow No. 10, FD and C Blue No. 1, magnesium stearate, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, silicon dioxide, sorbic acid, sorbitan monooleate, stearic acid, talc, titanium dioxide,and vanillin.500 mg tablets: hypromellose, hydroxypropyl cellulose, colloidal silicon dioxide, croscarmellosesodium, D and C Yellow No. 10, magnesium stearate, microcrystalline cellulose, povidone, propylene glycol, sorbic acid, sorbitan monooleate, titanium dioxide, and vanillin.Each yellow oval film-coated BIAXIN XL tablet (clarithromycin extended-release tablets) contains 500mg of clarithromycin and the following inactive ingredients: cellulosic polymers, D and C Yellow No. 10, lactose monohydrate, magnesium stearate, propylene glycol, sorbic acid, sorbitan monooleate, talc, titanium dioxide, and vanillin.After constitution, each 5 mL of Clarithromycin for Oral Suspension, USP contains 125mg or 250mg of clarithromycin. Each bottle of Clarithromycin for Oral Suspension, USP contains 1250mg (50 mL size), 2500 mg (50 and 100 mL sizes) or 5000 mg (100 mL size) of clarithromycin and the following inactive ingredients: carbomer, castor oil, citric acid, hypromellose phthalate, maltodextrin, potassium sorbate, povidone, silicon dioxide, sucrose, xanthan gum, titanium dioxide and fruit punch flavor.

Drug Information Provided by National Library of Medicine (NLM).

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