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Drug Information for Ceftriaxone for Injection USP 1 g (BAXTER HEALTHCARE CORPORATION): DESCRIPTION:
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Ceftriaxone for injection is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4-thiazolyl) glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl) thio]methyl]-5-thia-l-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 72-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.
The molecular formula of ceftriaxone sodium is C18H16N8Na2O7S3 . 3.5 H2O. It has a calculated molecular weight of 661.60 and the following structural formula:
Ceftriaxone for injection is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of ceftriaxone for injection solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used.
Ceftriaxone for injection contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity.
- Drug Information Provided by National Library of Medicine (NLM).