Drug Information for ADRENACLICK™ (epinephrine injection, USP) auto-injector (Sciele Pharma, Inc. ): DOSAGE AND ADMINISTRATION

The physician who prescribes Adrenaclick™ should review this Prescribing Information insert in detail with the patient. This review should include the proper use of Adrenaclick to ensure that subcutaneous or intramuscular injections are given into the anterolateral aspect of the thigh, through clothing if necessary. The accompanying Patient Information Leaflet and Wrap Label should also be reviewed with the patient.

Adrenaclick is capable of delivering one dose of either 0.15 mg or 0.3 mg (0.15 mL or 0.3 mL of epinephrine). This dose is available for auto-injection by the patient.

Selection of the appropriate Adrenaclick dosage strength is determined according to patient body weight.

The usual dose of epinephrine for allergic emergencies in patients who weigh 30 kilograms or greater is 0.3 mg (0.3 mL of epinephrine).

Since the doses of epinephrine delivered from Adrenaclick are fixed, the physician should consider other forms of injectable epinephrine if doses lower than those available from Adrenaclick are felt to be necessary. The prescribing physician should carefully assess each patient to determine the most appropriate dose of epinephrine, recognizing the life-threatening nature of the reactions for which this drug is being prescribed.

Patients should be instructed to periodically visually inspect the epinephrine solution for particulate matter and discoloration. If the solution contains particulate matter or develops a pinkish color or becomes darker than slightly yellow, the patient should immediately contact their physician for a replacement, since these changes indicate that the effectiveness of the drug product may be decreased.