Drug Information for ACETAMINOPHEN, ASPIRIN, AND CODEINE* PHOSPHATE CAPSULES: DOSAGE AND ADMINISTRATION

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  • Dosage should be adjusted according to severity of pain and response of the patient. It should be kept in mind, however, that tolerance to codeine can develop with continued use and that the incidence of untoward effects is dose related. Adult doses of codeine higher than 60 mg fail to give commensurate relief of pain but merely prolong analgesia and are associated with an appreciably increased incidence of undesirable side effects. Equivalently high doses in children would have similar effects.

    The dose of this combination product is limited by the amount of codeine phosphate per capsule. For adults, a single dose of codeine phosphate should not exceed 60 mg. For children, the usual recommended single dose is 0.5 mg/kg.

    For the capsule containing 15 mg or 30 mg of codeine phosphate, the usual adult dosage is one or two capsules every four hours as needed.

    For the capsule containing 60 mg of codeine phosphate, the usual adult dosage is one capsule every four hours as needed.

  • Drug Information Provided by National Library of Medicine (NLM).
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