Drug Information for 50% DEXTROSEInjection, USP (Hospira, Inc.): WARNINGS

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  • 50% Dextrose Injection is hypertonic and may cause phlebitis and thrombosis at the site of injection.

    Significant hyperglycemia and possible hyperosmolar syndrome may result from too rapid administration. The physician should be aware of the symptoms of hyperosmolar syndrome, such as mental confusion and loss of consciousness, especially in patients with chronic uremia and those with known carbohydrate intolerance.

    The intravenous administration of this solution can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema.

    Additives may be incompatible. Consult with pharmacist if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.

    For peripheral vein administration:

    The solution should be given slowly, preferably through a small bore needle into a large vein, to minimize venous irritation.

    For central venous administration:

    Concentrated dextrose should be administered via central vein only after suitable dilution.

  • Drug Information Provided by National Library of Medicine (NLM).
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