Disease Information for Zoledronic acid (Zometa/Reclast) Administration/Toxicity

Ads
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Renal Failure
Azotemia/Acute
Drug induced Renal failure,
Hypocalcemia
Osteonecrosis of Jaw
Toxic nephritis/Chronic persistent
Toxic Nephritis/Nephropathy
Disease Mechanism & Classification
Drugs
DRUG/Bisphosphonate drug (example)
DRUG/Induces osteoclast apoptosis/inhibition
DRUG/New release 2007
DRUG/Once a Year
DRUG/Once Every Two Years
DRUG/Specialized usage (example)
Pathophysiology
Pathophysiology/Osteoclast inhibition
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Zoledronic acid (Zometa Reclast) admin, Brand name/Reclast (Zoledronic Acid), Brand name/Zometa (Zoledronic acid)
Treatment
Drug Dosage
DRUG/.$$$$$ Most Expensive
DRUG/2002 new drug (RX)
DRUG/2003 New Drug (RX)
DRUG/Dose 5 mgm (Unit/Pill/Capsule size)
DRUG/Dose Bolus method/infusion rate (CONFIRM this)
DRUG/Dose Infusion mix 5 mgm/100 ml (CONFIRM this
DRUG/Dose Unit dose Vial preparation
DRUG/Injectable medication (parenteral)
DRUG/Injectable preparation only
DRUG/Intravenous administraton RX
-Renal excretion important pathway/drug
Definition

Bisphosphonate drug used in pagets disease and osteoporosis; parenteral preparation;this drug is a new bisphosphonate used for hypercalcemia of cancer; bony metastasis from solid tumors including prostate, breast and lung; also indicated for multiple myeloma; given as slow bolus of 4 mgm over 15 minutes; avoid in renal disease and keep well hydrated.-------------------------------------

Zoledronic acid can be given every 6–12 months in doses of 2–4 mg intravenously over 20 minutes; Postinfusion fever, fatigue, myalgia, and bone pain occur commonly and may sometimes be severe.

[current dxrx 2005 accessmedicine]

Reclast 5mgm/100 cc for pagest by glaxosmithkline brand

Note some confusion of spelling in the literatureZoledronic acid = Zolendronic Acid

(Edit)

External Links Related to Zoledronic acid (Zometa/Reclast) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
Ads