Disease Information for Zimmermann-Laband syndrome/ZLS (3p21.2)

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Associated Diseases & Rule outs
Associated Disease & Complications
Zimmermann-Laband syndrome
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
Pathophysiology
Pathophysiology/Gene locus 3p21.2
Pathophysiology/Gene locus chromosome 3
Pathophysiology/Gene locus Chromosome 3p
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Maternal Chromosome mutation
Process
PROCESS/Eponymic (category)
PROCESS/Eponymic/Esoteric/Not yet integrated into database
PROCESS/Genetic disorder/Spontaneous mutations/sporadic
PROCESS/INCIDENCE/Esoteric disease (example)
Synonyms
Synonym
Zimmermann Laband syndrome ZLS (3p21 2), Synonym/Laband gingival fibromplasia/dysmorphia, Synonym/Laband syndrome, Synonym/ZLS
Definition

Laband Syndrome; Gingival Fibromatosis, Abnormal Fingers, Nails, Nose, Ear, Splenomegaly; ZLS; Zimmermann-Laband Syndrome; Laband Syndrome is an extremely rare inherited disorder characterized by abnormalities of the head and facial (craniofacial) area and the hands and feet; Most children with this disorder have abnormally large gums (gingival fibromatosis); Overgrown gums may affect the ability to chew, swallow, and/or speak; In addition, affected infants may exhibit abnormally long, thin fingers and toes and/or deformed (dysplastic) or absent nails at birth; In some cases, mental retardation may also be present; Laband Syndrome is inherited as an autosomal dominant trait----------[NORD]---------------- gene locus 3p21-2

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External Links Related to Zimmermann-Laband syndrome/ZLS (3p21.2)
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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