Disease Information for Zileuton (Zyflo) Administration/Toxicity

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Associated Diseases & Rule outs
Rule Outs
Drug induced Hepatic toxicity
Associated Disease & Complications
Drug induced Hepatic toxicity
Toxic hepatitis
Zileuton (Zyflo) effect/toxicity
Disease Mechanism & Classification
Drugs
DRUG/ Source rDNA Manufacture
DRUG/Anti-asthma medication (example)
DRUG/Antileukotriene/asthma medication (example)
DRUG/Arachidonic acid metabolism changes/effect
DRUG/Genetically engineered/biological drug (example)
DRUG/Inhibitor/5-lipoxygenase/arachidonic/leukotrienes
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
Zileuton (Zyflo) admin, Brand name/Zyflo (Zileuton)
Treatment
Drug Therapy - Contraindication
RX/Theophylline (Theodur)
RX/Warfarin (Coumadin)
Drug Dosage
DRUG/.$$$$$ Most Expensive
DRUG/1999 Approx. New drug (RX)
DRUG/Dose 600 mgm (Unit/Pill/Capsule size)
DRUG/Dose QID Medication
DRUG/Oral medication (ex)
-Pharmacology/Metabolized in liver
Definition

An anti-asthma drug; A Cyclo-Oxygenase pathway (prostaglandins) inhibitor; As 5-lipoxygenase inhibitor; Oral preparation; Excellent for "Aspirin-asthma" syndrome and chronic bronchospasm

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External Links Related to Zileuton (Zyflo) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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