Disease Information for Wolff-Parkinson-White syndrome

Clinical Manifestations
Signs & Symptoms
Accentuated S1 heart sound
Cardiac Symptoms/Signs
Fast Constant Heart Rate 150-170
Heart rate >200
P2 early
Palpitations/Skipped beats
Tachycardia/Fast heart rate
Episodic symptoms/events
Near death experience/infant/SIDS survivor
Spells/Episodes of weakness
Disease Progression
Demographics & Risk Factors
Established Disease Population
Patient/Atrial fibrillation poor rate control
Population Group
Population/Pediatrics population
Sex & Age Groups
Diagnostic Test Results
Electrophysiologic/cardiac conduction study abnormal
EKG/Short PR interval (ECG)
EKG/Bizarre QRS patterns (ECG)
EKG/Intrinsicoid deflection QRS >.06 (ECG)
EKG/Pseudoinfarction pattern/Q Waves/atypical (ECG)
EKG/Wide QRS pattern tachycardia (ECG)
EKG/Widened QRS pattern (ECG)
EKG/Left-axis deviation (ECG)
EKG/Delta Waves anterior leads (ECG)
EKG/Nodal tachycardia (ECG)
EKG/Pre-exitation syndrome (ECG)
EKG/Abnormal in children
EKG/Changes/abnormalities (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Aberrancy supraventricular tachycardia
Atrial fibrillation
Atrial flutter
Cardiac arrest
Junctional re-entrant tachycardia/RJT
Nodal tachycardia/junctional rhythm/accelerated
Paroxysmal supraventricular tachycardia
Preexcitation syndrome/ventricular
Sudden death/Child
Supraventricular tachycardia
Wolff-Parkinson-White syndrome
WPW/Atrial Fibrillation 1/1 conduction
WPW/atrial flutter 1/1 conduction
Cardiac death, sudden
Sudden Death Young Athlete
Disease Mechanism & Classification
CLASS/Primary organ/system disorder (ex)
CLASS/Cardiovascular (category)
CLASS/Conduction system/cardiac disorder (ex)
CLASS/Heart disorder (ex)
Pathophysiology/Accessory pathway/cardiac conduction
Pathophysiology/Bundle of Kent conduction process
PROCESS/Eponymic (category)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Syndrome Wolf Parkinson White, Syndrome Wolff Parkinson White, Syndrome WPW, Ventricular pre excitation with arrhythmia, Wolf Parkinson White Syndrome, Wolff Parkinson White syndrome, Wolff Park White syndr, Wolff Parkinson White (WPW) syndrome, Wolff Parkinson White pattern, Wolff Parkinson White pattern (disorder), Wolff Parkinson White pattern (finding), WOLFF PARKINSON WHITE SYNDROME, WOLFF PARKINSON WHITE SYNDROME CONGENITAL, wpw, WPW syndrome, WPW Wolff Park White pattern, WPW Wolff Parkinson White pattern, WPW Wolff Parkinson White syndrome, WPW SYNDROME, Synonym/Anomalous atrioventricular excitation, Synonym/Preexcitation syndrome of WPW, Synonym/WPW syndrome
Drug Therapy - Contraindication
RX/Adenosine (Adenocard)
RX/Digoxin (Lanoxin)
RX/Verapamil (Calan)
Drug Therapy - Indication
RX/Disopyramide (Norpace)
RX/Procainamide (Pronestyl)
RX/Propranolol (Inderal)
RX/Quinidine (Quinaglute)
SX/Catheter cardiac conduction/locus ablation

A form of pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave-----------------------Wolff Parkinson White Syndrome

Accessory Atrioventricular Pathways; Preexcitation Syndrome

WPW Syndrome; Wolff-Parkinson-White Syndrome is a rare disorder involving cardiac arrhythmia; Patients have an extra circuit or pathway, called the Bundle of Kent, through which electrical signals are conducted to the heart, allowing excessive stimulation; Palpitations (sensation of rapid or irregular beating of the heart), weakness, and shortness of breath may occur--[NORD 2005]----

Tachycardias involving accessory pathways are called reciprocating tachycardias (RT); In the most common form, activation is from atria to ventricles through the normal

A- V node returning via the accessory pathway to the atria; A narrow QRS tachycardia results, during which P waves are inscribed after the QRS complex; This direction of tachycardia is called orthodromic; Very rarely, conduction may be in the opposite direction, when a broad QRS complex antedromic RT results; Accessory pathways (eg, Kent bundle), which link the atria and ventricles bypassing the A-V node, are responsible for the Wolff-Parkinson-White (WPW) syndrome; In affected patients, a typical ECG pattern of short PR interval and slurred QRS complex (d wave) is associated with arrhythmias; Antegrade conduction over the accessory pathway is necessary to create the short PR interval and the d wave, but it is retrograde conduction that is important for sustaining orthodromic RT; Thus, a concealed accessory pathway (normal PR, no d wave in sinus rhythm) may support the arrhythmia;


External Links Related to Wolff-Parkinson-White syndrome
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)