Disease Information for Waterhouse-Friderichsen syndrome

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Clinical Manifestations
Signs & Symptoms
Capillary Refill Time/CRT Abnormal
Falling blood pressure/progessive/signs
Low Blood Pressure
Signs of Poor Perfusion
Bruising/Ecchymosis
Fever and Rash
Hemorrhagic rash
Hemorrhagic/Confluent ecchymotic rash
Non-pruritic rash
Petechiae/Petechial rash
Purpura
Purpura, Generalized
Rash
Rash hand/foot areas
Excessive/easy bruising tendency
Renal Mass
Kidney Mass
Acute sepsis syndrome
Collapse/Prostration
Fever
Fever Febrile Possible
Flu-Like Syndrome
High body temperature
Mucous membrane pallor
Toxic and Febrile Septic
Disease Progression
Course/Acute
Course/Catastrophic presentation/onset
Onset/Abrupt/Sudden
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Children/all
Laboratory Tests
Microbiology & Serology Findings
Microlab/Niesseria meningococcus isolation/agent
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Fasting hypoglycemia (Lab)
Abnormal Lab Findings - Decreased
Bicarbonate, serum (Lab)
Carbon Dioxide Total Content/CO2
Cortisol (Lab)
Glucose, blood (Lab)
URINE Cortisol/Free Cortisol
URINE Free Cortisol/24 Hour
Diagnostic Test Results
CT Scan
CT Scan/Adrenal abnormality
CT Scan/Adrenal mass
CT Scan/Adrenal Mass Bilateral
Image Scan/Unilateral Adrenal mass
MRI/Adrenal mass/Abdomen
MRI/Bilateral Adrenal Masses/abdomen
X-RAY
Xray/Adrenal calcifications/bilateral/KUB
Associated Diseases & Rule outs
Associated Disease & Complications
Addison's disease
Adrenal hemorrhage
Adrenocortical insufficiency
Coma/Unconscious
Glucocorticoid Deficiency
Hypoglycemia
Hypotension
Hypovolemia
Hypovolemic shock
Purpura fulminans
Shock
Disease Mechanism & Classification
Class
CLASS/Adrenal gland disorders (ex).
CLASS/Endocrine gland (category)
Pathophysiology
Pathophysiology/Gangrene/skin/subcutaneous tissue
Activated Protein C Resistance
Pathophysiology/Activated protein C failure/deficit
Pathophysiology/Intravasular coagulation process
Pathophysiology/Spontaneous Coagulation
Pathophysiology/Generalized Shwartzman reaction
Process
PROCESS/Complicating disorder (ex)
PROCESS/Complicating/Specific process disorder (ex)
PROCESS/Complication/primary failed organ/system (ex)
PROCESS/Eponymic (category)
Synonyms
Synonym
Purpura Fulminans (Waterhouse Friderichsen Syndrome), Waterhouse Friderichen, Waterhouse Friderichsen Syndrome, Waterhouse Friederichsen Syndrome, Synonym/Adrenal apoplexy with meningococcemia, Synonym/Adrenal hemorrhage syndrome, Synonym/Meningococcic adrenal hemorrhage
Treatment
Drug Therapy - Indication
RX/Activated protein C (Xigris)
RX/Corticosteroid (Cortisone)
RX/Fluid/electrolytes intravenous
Definition

A condition characterized by the abrupt onset of fever, petechiae, ARTHRALGIA, weakness, and myalgias followed by acute hemorrhagic necrosis of the adrenal glands and severe cardiovascular dysfunction; The syndrome is most often associated with meningococcal septicemia but may occur as a complication of sepsis caused by other organisms, including certain STREPTOCOCCUS species; This disorder may be associated with a prior history of SPLENECTOMY--------(From J Emerg Med 1998 Jul-Aug;16(4):643-7)--------------

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External Links Related to Waterhouse-Friderichsen syndrome
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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