Disease Information for Warfarin embryopathy syndrome

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Clinical Manifestations
Signs & Symptoms
Particular physiognomy/Odd looking kids
Craniofacial Abnormalities/Congenital
Depressed nasal bridge
Midfacial hypoplasia/flat face dysmorphism
Wide spaced hypoplastic nipples/girl
Absent Nails/Aplasia
Nails hypoplastic/dysplastic
Small nails/congenital
Low birth weight/newborn/SGA/Small for gestational age
Hypotonia
Delayed speech/language development
Developmental milestones delayed
Mental Deficiency Child
Seizures
Short fingers/toes (Brachydactyly)
Growth/development delay
Corneal opacity
Clinical Presentation & Variations
Presentation/Multiple deformities newborn (odd look)
Disease Progression
Course/Acute
Demographics & Risk Factors
Established Disease Population
Patient/Anticoagulated
Diagnostic Test Results
X-RAY
Xray/Punctate epiphyses long bones
Associated Diseases & Rule outs
Associated Disease & Complications
Airway obstruction
Cataract
Choanal atresia
Chondrodysplasia punctata
Corpus callosum defect/agenesis
Drug induced Potential fetal/anomaly
Fetal anomaly
Fetal damage/teratogenic effect
Hydrocephalus
Meningoencephalocele
Mental retardation
Microcephaly/oligophrenia
Patent ductus arteriosis
Pulmonary veins, anomalous drain/hepatic
Pulmonary veins/anomalous return/right atrium
Pulmonic valve stenosis
Transposition great vessels
Warfarin embryopathy syndrome
Disease Mechanism & Classification
Class
CLASS/Pediatric disorders (ex)
CLASS/Fetus disorder (ex)
Drugs
DRUG/Maternal medication/fetal effect
DRUG/Teratogenic potential/effect (D plus )
Pathophysiology
Pathophysiology/Fetal Drug Effect Syndrome
Pathophysiology/Fetus Exposed First Trimester
Process
PROCESS/Complicating disorder (ex)
PROCESS/Complicating/Specific process disorder (ex)
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
PROCESS/Poison/specific (category)
PROCESS/Poisoned organ/system (category)
PROCESS/Dystostosis/craniofacial (ex)
Synonyms
Synonym
congenital warfarin syndrome, Coumadin syndrome, coumarin syndrome, DiSala syndrome, Dysmorphism due to warfarin, dysmorphism warfarin, fetal anticoagulant syndrome, Fetal warfarin syndrome, Fetal warfarin syndrome (disorder), Foetal warfarin syndrome, heparin embryopathy, warfarin dysmorphism, warfarin embryopathy, Warfarin syndrome, Synonym/Congenital warfarin syndrome, Synonym/Coumarin embryopathy, Synonym/DiSala syndrome, Synonym/Fetal Anticoagulant syndrome
Definition

Teratogenic fetal pattern syndrome; Anticoagulant Vitamin K antagonist; oral preparation; very common use for most outpatient anticoagulation; very teratogenic and contra-indicated in pregnancy; Multiple abnormalities in infants whose mother were treated with coumarin anticoagulants during pregnancy; The most common anomalies include developmental delay, neurological complications (usually hydrocephalus and occasional agenesis of the corpus callosum and meningoencephalocele), midfacial hypoplasia, and various ocular, skeletal, and other defects-----[Jablonski/NIH Archives 2007]--------

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External Links Related to Warfarin embryopathy syndrome
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Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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