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Disease Information for Warfarin embryopathy syndrome
- Clinical Manifestations
- Signs & Symptoms
- Particular physiognomy/Odd looking kids
- Craniofacial Abnormalities/Congenital
- Depressed nasal bridge
- Midfacial hypoplasia/flat face dysmorphism
- Wide spaced hypoplastic nipples/girl
- Absent Nails/Aplasia
- Nails hypoplastic/dysplastic
- Small nails/congenital
- Low birth weight/newborn/SGA/Small for gestational age
- Hypotonia
- Delayed speech/language development
- Developmental milestones delayed
- Mental Deficiency Child
- Seizures
- Short fingers/toes (Brachydactyly)
- Growth/development delay
- Corneal opacity
- Clinical Presentation & Variations
- Presentation/Multiple deformities newborn (odd look)
- Disease Progression
- Course/Acute
- Demographics & Risk Factors
- Established Disease Population
- Patient/Anticoagulated
- Diagnostic Test Results
- X-RAY
- Xray/Punctate epiphyses long bones
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Airway obstruction
- Cataract
- Choanal atresia
- Chondrodysplasia punctata
- Corpus callosum defect/agenesis
- Drug induced Potential fetal/anomaly
- Fetal anomaly
- Fetal damage/teratogenic effect
- Hydrocephalus
- Meningoencephalocele
- Mental retardation
- Microcephaly/oligophrenia
- Patent ductus arteriosis
- Pulmonary veins, anomalous drain/hepatic
- Pulmonary veins/anomalous return/right atrium
- Pulmonic valve stenosis
- Transposition great vessels
- Warfarin embryopathy syndrome
- Disease Mechanism & Classification
- Class
- CLASS/Pediatric disorders (ex)
- CLASS/Fetus disorder (ex)
- Drugs
- DRUG/Maternal medication/fetal effect
- DRUG/Teratogenic potential/effect (D plus )
- Pathophysiology
- Pathophysiology/Fetal Drug Effect Syndrome
- Pathophysiology/Fetus Exposed First Trimester
- Process
- PROCESS/Complicating disorder (ex)
- PROCESS/Complicating/Specific process disorder (ex)
- PROCESS/Medication/Drug (CONFIRM dose/before treatment)
- PROCESS/Poison/specific (category)
- PROCESS/Poisoned organ/system (category)
- PROCESS/Dystostosis/craniofacial (ex)
- Synonyms
- Synonym
- congenital warfarin syndrome, Coumadin syndrome, coumarin syndrome, DiSala syndrome, Dysmorphism due to warfarin, dysmorphism warfarin, fetal anticoagulant syndrome, Fetal warfarin syndrome, Fetal warfarin syndrome (disorder), Foetal warfarin syndrome, heparin embryopathy, warfarin dysmorphism, warfarin embryopathy, Warfarin syndrome, Synonym/Congenital warfarin syndrome, Synonym/Coumarin embryopathy, Synonym/DiSala syndrome, Synonym/Fetal Anticoagulant syndrome
- Definition
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Teratogenic fetal pattern syndrome; Anticoagulant Vitamin K antagonist; oral preparation; very common use for most outpatient anticoagulation; very teratogenic and contra-indicated in pregnancy; Multiple abnormalities in infants whose mother were treated with coumarin anticoagulants during pregnancy; The most common anomalies include developmental delay, neurological complications (usually hydrocephalus and occasional agenesis of the corpus callosum and meningoencephalocele), midfacial hypoplasia, and various ocular, skeletal, and other defects-----[Jablonski/NIH Archives 2007]--------
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- External Links Related to Warfarin embryopathy syndrome
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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