Disease Information for Vitamin E deficiency

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Clinical Manifestations
Signs & Symptoms
Edema Children
Malnourished/poor nutrition status/signs
Edema of Lower Extremities
Muscle weakness
Absent deep tendon reflexes
Absent knee reflexes
Ankle reflexes absent
Ataxia
Awkward Uncoordinated Child
Cerebellar movement disorder/signs
Cerebellar signs
Dysarthria
Dysdiadochokinesia/Alternating failure
Hyporeflexia/DTRs decreased
Lhermittes sign (tingling on neck flex)
Limb Ataxia
Limb ataxia/clumsiness child
Loss position sense/postural sense
Neurologic manifestations/signs
Position sense decreased/proprioception
Position sense decreased/proprioception Legs
Sensory defects/lower extremities
Slurred speech
Slurred Speech/Acute
Slurred speech/Chronic
Staggering Gait
Truncal ataxia
Unable to tandem walk/straight line
Vibratory sense decreased
Vibratory sense decreased Legs
Difficulty Talking
Walking difficulties
Weakness
Double Image Vision Confirmed
Eyelid Retraction
Proptosis,bilateral
Ptosis (blepharoptosis)
Retinal pigmentation
Clinical Presentation & Variations
Anemia in Children
Presentation/Ataxia in a Child Acute
Demographics & Risk Factors
Established Disease Population
Patient/Malnourished/starved
Patient/Malabsorption syndrome
Laboratory Tests
Microbiology & Serology Findings
Reticulocytosis
Abnormal Lab Findings - Decreased
Factor 2/Prothrombin (Lab)
Hemoglobin (Lab)
Abnormal Lab Findings - Increased
CPK/CK/Creatine kinase/Creatine phosphokinase (Lab)
Polychrome RBCs (Lab)
Reticulocytes (Lab)
URINE Creatine
URINE Hemoglobin
Diagnostic Test Results
Pathology
BX/Muscle Biopsy Abnormal
BX/Muscle biopsy/Ceroid deposition
Associated Diseases & Rule outs
Rule Outs
Ataxia-telangiectasia
Friedreich's Ataxia
Tabes dorsalis
Associated Disease & Complications
Carcinomatous cerebellar/motor syndrome
Cerebellar ataxia
Edema
Exophthalmos
Hemoglobinuria
Hemolysis anemia/acute/active
Hereditary Blindness
Myelopathy manifestations/involvement
Ophthalmoplegia
Peripheral neuropathy
Polyneuritis
Retinal Degeneration/Dystrophy
Retinitis pigmentosa
Vitamin E deficiency
Ataxia Disorder
Polyneuropathy
Disease Synergy - Causes
Synergy/Malabsorption syndrome
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Hemolytic process/effect
Pathophysiology/Acquired Neuropathy
Pathophysiology/Posterior columns cord def
Process
PROCESS/Deficiency (category)
Synonyms
Synonym
DEFIC VITAMIN E, Deficiencies Vitamin E, Deficiency of vitamin E, deficiency vitamin E, Hypovitaminosis E, vitamin deficiency E, VITAMIN E DEFIC, Vitamin E Deficiencies, Vitamin E deficiency, Vitamin E deficiency (disorder), Vitamin E deficiency disease, Early Onset Ataxia/Children
Treatment
Drug Therapy - Indication
RX/Vitamin E
Definition

A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration; In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia; An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed,)-----------------------.

In general, tocopherols act as antioxidants to prevent lipid peroxidation of polyunsaturated fatty acids in cellular membranes; The antioxidant activity of -tocopherol is similar to that of glutathione peroxidase, which contains selenium; the main manifestations of vitamin E deficiency are (1) mild hemolytic anemia associated with increased erythrocyte hemolysis and (2) spinocerebellar disease , which occurs mainly in children who have fat malabsorption due to abetalipoproteinemia, chronic cholestatic hepatobiliary disease, celiac disease, or a genetic abnormality in vitamin E metabolism; Retinopathy of prematurity, also called retrolental fibroplasia, may improve with vitamin E therapy, and hemorrhage in the newborn; Infants are born in a state of relative vitamin E deficiency, with plasma -tocopherol levels below 5 µg/mL; The smaller and more premature the infant, the greater the degree of deficiency; Vitamin E deficiency in premature infants persists during the first few weeks of life and can be attributed to limited placental transfer of vitamin E, low tissue levels at birth, relative dietary deficiency in infancy, intestinal malabsorption, and rapid growth; As the digestive system matures, vitamin E absorption improves, and blood vitamin E levels rise; malabsorption generally underlies vitamin E deficiency; Genetic abnormality in the transport of vitamin E can also play a role; Hemolytic anemia in premature infants may be a manifestation of vitamin E deficiency; Such an infant has hemoglobin levels ranging from 7 to 9 g/dL, low plasma vitamin E levels, reticulocytosis, and hyperbilirubinemia;

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External Links Related to Vitamin E deficiency
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Wikipedia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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