Disease Information for Vitamin B12 deficiency

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Clinical Manifestations
Signs & Symptoms
Gray Hair
Gray hair Childhood
Gray hair, premature
Hyperpigmented discrete macules/palms/soles
Increased pigmentation/tanning/hyperpigmented
Pigmented lines/fingernails
Pigmented/skin folds/flexor/palmar creases
White Hair
Anorexia Decreased appetite
Anorexia in Elderly
Malnourished/poor nutrition status/signs
Buccal pigmentations
Decreased taste ability/Hypoguesia
Oral pigmentation lesions
Tongue lesion/sign
Acroparesthesias Acral Paresthesias
Leg cramps,nocturnal
Ataxia
Ataxia/Posterior columns
Chorea signs
Delirium
Focal neurologic deficit
Hypesthesia
Hyporeflexia/DTRs decreased
Lhermittes sign (tingling on neck flex)
Loss of Taste
Paresthesias
Personality change
Sensory Ataxia
Staggering Gait
Symmetric Polyneuropathy
Anosmia/Loss of sense of smell
Clinical Presentation & Variations
Anemia with Low Reticulocyte Count
Presentation/Progressive Motor Sensory Polyneuropathy
Disease Progression
Pancytopenia with Normal Marrow
Demographics & Risk Factors
Past History
Past history/Gastrectomy
Established Disease Population
Patient/Hyperalimentation
Patient/Pellagra/niacin deficiency
Patient/Atrophic gastritis
Patient/Crohns/regional enteritis
Patient/Gastric Bypass
Patient/Inflammatory Bowel Disease
Patient/Jejunocolic bypass
Patient/Malabsorption syndrome
Laboratory Tests
Microbiology & Serology Findings
Reticulocytosis
Abnormal Lab Findings (Non Measured)
Macrocytic anemia (Lab)
Macrocytosis/smear (Lab)
Abnormal Lab Findings - Decreased
Neutrophiles (Lab)
Platelet count (Lab)
Reticulocytes (Lab)
Abnormal Lab Findings - Increased
Bilirubin, serum (Lab)
Hemoglobin (Lab)
Homocysteine serum (Lab)
Indirect bilirubin (Lab)
Iron, serum (Lab)
MCV/Mean Corpuscular Volume (Lab)
Mean Platelet Volume (MPV)
Methylmalonate (LAB)
Methylmalonic acid/CoA serum (MMA) (Lab)
RDW/Red cell size variance (Lab)
Diagnostic Test Results
Pathology
Bone Marrow/Giant metamyelocytes
Bone Marrow/Maturation arrest/granulocytes
Bone Marrow/Megaloblastic/Pathology
PATH/Brain Focal Degeneration/Lesion
Associated Diseases & Rule outs
Rule Outs
Burning Mouth Syndrome
Myelodysplasia
Optic neuritis
Tabes dorsalis
Associated Disease & Complications
Anemia
Atrophic glossitis/Glossitis
Bilirubinemia
Burning Mouth Syndrome
Combined system disease/B12 deficiency
Hyperpigmentation
Hypovitaminosis B12
Megaloblastic anemia/disease
Metabolic encephalopathy
Pancytopenia
Paraplegia, spastic
Peripheral neuropathy
Polyneuritis
Posterior column disease/cord
Secondary Psychosis/Symptomatic
Sensory neuropathy
Thrombocytopenia
Vitamin B12 deficiency
Ataxia Disorder
Demyelinating Disease
Polyneuropathy
Disease Mechanism & Classification
Class
CLASS/Erythrocyte disorder (ex)
CLASS/Hematologic (category)
Pathophysiology
Pathophysiology/Nucleotide biosyn/one-carbon failure
Pathophysiology/Deficiency hematologic effect (ex)
Pathophysiology/Ineffective erythropoesis
Pathophysiology/Intramedullary hemolysis
Pathophysiology/Acquired Neuropathy
Pathophysiology/Demyelination
Process
PROCESS/Deficiency (category)
PROCESS/Water-soluble vitamin deficiencies (ex)
Definition

A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia; Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations; A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis; (From Cecil Textbook of Medicine, 19th ed, p848)-------------------------------------------------Vitamin B12 Deficiency ;Cobalamin Deficiency;

Vitamin B12 Deficiency is characterized by an abnormally low blood levels of this vitamin; The disorder can be caused by a poor diet, inadequate absorption or utilization of B12 that may follow stomach and intestinal surgery or an increase in certain intestinal organisms; The deficiency causes changes in the blood and the central nervous system; Injection of this vitamin usually cures the disorder if the underlying cause can be corrected-------------[NORD 2005]---------------

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External Links Related to Vitamin B12 deficiency
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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