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- Disease Information
- Disease Comparison
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Disease Processes ▼
- Auto Immune
- Vascular-Arteriosclerosis
- Biochemical
- Congenital-developmental
- Deficiency
- Degenrative-Necrosis
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Major Organs-Systems ▼
- Systemic
- Pediatric
- Nervous & Sensory System (Neurology)
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- Urinary System
- Dermatologic System
- Endocrine System
- Immune System
- Musculoskeletal System
- Genital Reproductive System
- Hematopoietic System (Hematology)
- Lymphatic System
- Tissue/Cells/Organelles
Disease Information for Vitamin B12 deficiency
- Clinical Manifestations
- Signs & Symptoms
- Gray Hair
- Gray hair Childhood
- Gray hair, premature
- Hyperpigmented discrete macules/palms/soles
- Increased pigmentation/tanning/hyperpigmented
- Pigmented lines/fingernails
- Pigmented/skin folds/flexor/palmar creases
- White Hair
- Anorexia Decreased appetite
- Anorexia in Elderly
- Malnourished/poor nutrition status/signs
- Buccal pigmentations
- Decreased taste ability/Hypoguesia
- Oral pigmentation lesions
- Tongue lesion/sign
- Acroparesthesias Acral Paresthesias
- Leg cramps,nocturnal
- Ataxia
- Ataxia/Posterior columns
- Chorea signs
- Delirium
- Focal neurologic deficit
- Hypesthesia
- Hyporeflexia/DTRs decreased
- Lhermittes sign (tingling on neck flex)
- Loss of Taste
- Paresthesias
- Personality change
- Sensory Ataxia
- Staggering Gait
- Symmetric Polyneuropathy
- Anosmia/Loss of sense of smell
- Clinical Presentation & Variations
- Anemia with Low Reticulocyte Count
- Presentation/Progressive Motor Sensory Polyneuropathy
- Disease Progression
- Pancytopenia with Normal Marrow
- Demographics & Risk Factors
- Past History
- Past history/Gastrectomy
- Established Disease Population
- Patient/Hyperalimentation
- Patient/Pellagra/niacin deficiency
- Patient/Atrophic gastritis
- Patient/Crohns/regional enteritis
- Patient/Gastric Bypass
- Patient/Inflammatory Bowel Disease
- Patient/Jejunocolic bypass
- Patient/Malabsorption syndrome
- Laboratory Tests
- Microbiology & Serology Findings
- Reticulocytosis
- Abnormal Lab Findings (Non Measured)
- Macrocytic anemia (Lab)
- Macrocytosis/smear (Lab)
- Abnormal Lab Findings - Decreased
- Neutrophiles (Lab)
- Platelet count (Lab)
- Reticulocytes (Lab)
- Abnormal Lab Findings - Increased
- Bilirubin, serum (Lab)
- Hemoglobin (Lab)
- Homocysteine serum (Lab)
- Indirect bilirubin (Lab)
- Iron, serum (Lab)
- MCV/Mean Corpuscular Volume (Lab)
- Mean Platelet Volume (MPV)
- Methylmalonate (LAB)
- Methylmalonic acid/CoA serum (MMA) (Lab)
- RDW/Red cell size variance (Lab)
- Diagnostic Test Results
- Pathology
- Bone Marrow/Giant metamyelocytes
- Bone Marrow/Maturation arrest/granulocytes
- Bone Marrow/Megaloblastic/Pathology
- PATH/Brain Focal Degeneration/Lesion
- Associated Diseases & Rule outs
- Rule Outs
- Burning Mouth Syndrome
- Myelodysplasia
- Optic neuritis
- Tabes dorsalis
- Associated Disease & Complications
- Anemia
- Atrophic glossitis/Glossitis
- Bilirubinemia
- Burning Mouth Syndrome
- Combined system disease/B12 deficiency
- Hyperpigmentation
- Hypovitaminosis B12
- Megaloblastic anemia/disease
- Metabolic encephalopathy
- Pancytopenia
- Paraplegia, spastic
- Peripheral neuropathy
- Polyneuritis
- Posterior column disease/cord
- Secondary Psychosis/Symptomatic
- Sensory neuropathy
- Thrombocytopenia
- Vitamin B12 deficiency
- Ataxia Disorder
- Demyelinating Disease
- Polyneuropathy
- Disease Mechanism & Classification
- Class
- CLASS/Erythrocyte disorder (ex)
- CLASS/Hematologic (category)
- Pathophysiology
- Pathophysiology/Nucleotide biosyn/one-carbon failure
- Pathophysiology/Deficiency hematologic effect (ex)
- Pathophysiology/Ineffective erythropoesis
- Pathophysiology/Intramedullary hemolysis
- Pathophysiology/Acquired Neuropathy
- Pathophysiology/Demyelination
- Process
- PROCESS/Deficiency (category)
- PROCESS/Water-soluble vitamin deficiencies (ex)
- Definition
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A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia; Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations; A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis; (From Cecil Textbook of Medicine, 19th ed, p848)-------------------------------------------------Vitamin B12 Deficiency ;Cobalamin Deficiency;
Vitamin B12 Deficiency is characterized by an abnormally low blood levels of this vitamin; The disorder can be caused by a poor diet, inadequate absorption or utilization of B12 that may follow stomach and intestinal surgery or an increase in certain intestinal organisms; The deficiency causes changes in the blood and the central nervous system; Injection of this vitamin usually cures the disorder if the underlying cause can be corrected-------------[NORD 2005]---------------
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- External Links Related to Vitamin B12 deficiency
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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