Disease Information for Vinorelbine (Navelbine) Administration/Toxicity

Cancer chemotherapy drug; Vinca alkaloid class; Vinorelbine is a vinca alkaloid that interferes with microtubule assembly; The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine; Unlike other vinca alkaloids, the catharanthine unit is the site of structural modification for vinorelbine; The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin; Like other vinca alkaloids, vinorelbine may also interfere with: (1) amino acid, cyclic AMP, and glutathione metabolism; (2) calmodulin- dependent Ca++- transport ATPase activity; (3) cellular respiration; and (4) nucleic acid and lipid biosynthesis; In intact tectal plates from mouse embryos, vinorelbine, vincristine, and vinblastine inhibited mitotic microtubule formation at the same concentration , inducing a blockade of cellsat metaphase; based on experience with other anticancer vinca alkaloids, dose adjustments are recommended for patients with impaired hepatic function;

The pharmacokinetics of vinorelbine are not influenced by the concurrent administration of cisplatin with vinorelbine tartrate; CLINICAL STUDIES : Data from one randomized clinical study (211 evaluable patients) with single- agent vinorelbine tartrate injection and two randomized clinical trials (1044 patients) using vinorelbine tartrate injection combined with cisplatin support the use of vinorelbine tartrate injection in patients with advanced nonsmall cell lung cancer (NSCLC); Vinorelbine Tartrate Injection in Combination With Cisplatin [Vinorelbine Tartrate Injection + Cisplatin versus Single-Agent Cisplatin]

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