Disease Information for Valproic acid (Depakene) Administration/Toxicity

Ads
Clinical Manifestations
Signs & Symptoms
Yellow skin discoloration
Nausea
Vomiting
Athetosis
Choreoathetoid movement
Stupor/poor reponse to stimulus
Tremor
Clinical Presentation & Variations
Presentation/Pancreatitis Kids Recurrent
Laboratory Tests
Abnormal Lab Findings - Decreased
FTI/Free Thyroxin Index (Lab)
Abnormal Lab Findings - Increased
Anion gap (Lab)
Platelet count (Lab)
Sodium, serum (Lab)
Diagnostic Test Results
Pathology
BX/Liver biopsy/Fatty change in liver tissue
BX/Liver Microvesicular fatty subcellular organelles
Associated Diseases & Rule outs
Associated Disease & Complications
Craniorachischisis/Neural tube defect
Drug induced Balance/Ataxia poblems
Drug Induced Choreoathetosis
Drug induced Hepatic toxicity
Drug induced Pancreatitis
Drug induced Potential fetal/anomaly
Drug induced Thrombocytopenia.
Drug induced tremor/movement disorder
Drug interaction often
Fatty liver
Fetal anomaly
Fetal Valproate/Valproic Syndrome
Fulminant hepatic failure
Hypernatremia
Hypoglycemia
Pancreatitis, acute
Sedation/torpor induced
Spina bifida
Spina bifida occulta
Thrombocytopenia
Thrombocytosis
Toxic hepatitis
Disease Mechanism & Classification
Drugs
DRUG/Anticonvulsant/antiepilepsy medication (example)
DRUG/Mood stabilizer/Anti-manic bimodal medication
DRUG/Oral contraceptive effect weakened
DRUG/Probably NOT safe/Pregnancy category C drug
DRUG/Psychoactive/sedative drug (category)
DRUG/Teratogenic potential/effect (D plus )
DRUG/Teratogenic/OBGYN Class X/Pregnancy DANGER
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Toxin
TOXIN/Indication for Dialysis
TOXIN/NOT Diagnosed on USUALToxic screens
Synonyms
Synonym
2 Propylpentanoic Acid, 2 Propylvaleric Acid, Acid Valproic, Di n propylacetic Acid, Dipropylacetic acid, DIVALPROEX, DIVALPROEX PREPARATION, divalproex sodium (as valproic acid), DPA, Pentanoic acid 2 propyl, VA, Valproic acid, Valproic acid (product), Valproic acid (substance), VALPROIC ACID PREPARATION, Brand name/Depacon (Valproic acid), Brand name/Depakene (Valproic acid), Brand name/Depakote (Divalproex), Brand name/Deproic (Valproic acid), Brand name/Epiject (Valproic acid), Brand name/Epival (Valproic acid)
Treatment
Drug Therapy - Indication
RX/Naloxone (Narcan)
Drug Dosage
DRUG/.$$$$ Very Expensive
DRUG/Dose 125 mgms (Unit/Pill/Capsule size)
DRUG/Dose Extended time release/XT/SA (example)
DRUG/Dose guided by blood levels
DRUG/Dose liquid/syrup/suspension form
DRUG/Dose TID Medication
DRUG/Generic available
DRUG/Injectable medication (parenteral)
DRUG/Intravenous administraton RX
DRUG/IV requires lesser dose/Caution
DRUG/Oral medication (ex)
Other Treatments
TX/Dialysis.
Definition

Anticonvulsant antiepileptic drug often used in combination therapy; sometimes in neuropathic pain syndromes and as mood stabilizer

(Edit)

External Links Related to Valproic acid (Depakene) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
Ads