Disease Information for Urticaria, cholinergic

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Clinical Manifestations
Signs & Symptoms
Excoriations
Pruritic/itching rash
Rash
Associated Diseases & Rule outs
Rule Outs
Anaphylaxis, generalized
Angioedema/angioneurotic edema
Carcinoid syndrome/metastatic carcinoid
Associated Disease & Complications
Chronic hives/urticaria
Urticaria/hives
Disease Mechanism & Classification
Pathophysiology
Pathophysiology/Histamine cellular release
Treatment
Drug Therapy - Indication
RX/Antihistamine medication
Definition

Urticaria, Cholinergic; Physical Urticaria, Cholinergic Type; Cholinergic urticaria is a relatively common disorder of the immune system characterized by an immediate skin reaction (hypersensitivity) to heat, emotional stress, and/or exercise; Symptoms of the disorder include the appearance of distinctive small skin eruptions (hives) with well-defined borders and pale centers, surrounded by patches of red skin (wheal-and-flare reaction); These red areas are typically intensely itchy (pruritus); Occasionally, cholinergic urticaria may be associated with systemic symptoms such as fever and/or difficulty

breathing; The symptoms of cholinergic urticaria may develop due to the reaction of specific immune system antibodies (IgE) to certain antigens, leading to a hypersensitivity response (Type I) and the wheal-and-flare reaction that is typical of cholinergic urticaria------------------------[NORD website 2006]-------------

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External Links Related to Urticaria, cholinergic
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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