Disease Information for Troglitazone (Rezulin) Administration/Toxicity

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Clinical Manifestations
Clinical Presentation & Variations
Presentation/Diabetic Decreased need for Insulin
Presentation/Increasing insulin sensitivity Diabetic
Associated Diseases & Rule outs
Associated Disease & Complications
Congestive heart failure
Drug induced Hepatic toxicity
Drug induced Hypoglycemia
Hypoglycemia
Hypoglycemia, diabetic/treatment
Toxic hepatitis
Disease Synergy - Causes
Synergy/Insulin administration
Disease Mechanism & Classification
Drugs
DRUG/Anti-diabetic medication (example)
DRUG/Glitazone diabetic drug (example)
DRUG/Increased insulin receptor protein/effect
DRUG/Increases insulin sensitivity
DRUG/PPAR Agonist diabetic medication
DRUG/Thiazolidinedione antidiabetic medication (ex)
DRUG/TZD Oral anti-diabetic medication
Pathophysiology
Pathophysiology/Insulin sensitive effect
Pathophysiology/Insulin resistant states
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
admin (TOXIC), Troglitazone (Rezulin), Brand name/Rezulin (Troglitazone)TOXIC, Synonym/Thiobendizione admin
Treatment
Drug Dosage
DRUG/1996 Approx new drug (RX)
DRUG/Dose 200 mgms (Unit/Pill/Capsule size)
DRUG/Drug discontinued/TOXIC (RX)
DRUG/Oral medication (ex)
Definition

Anti-diabetic drug. Insulin resistance reducer. First of the newer major drug class of thiazolidinediones. TOXIC withdrawn because of liver complications.

PPAR Agonist [Peroxisome Proliferator-Activated Receptor]

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External Links Related to Troglitazone (Rezulin) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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