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- Disease Information
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Disease Information for Transfusion Related Acute Lung Injury/TRALI syndrome
- Clinical Manifestations
- Signs & Symptoms
- Acute Chest Pain
- Chest Pain
- Cyanosis
- Low Blood Pressure
- Signs of Poor Perfusion
- Cough
- Dyspnea
- Dyspnea at rest
- Rales
- Rales,fine dry diffuse
- Rapid Breathing
- Respiratory distress
- Shortness of breath/SOB
- Tachypnea/Increased respiratory rate
- Fever
- Flu-Like Syndrome
- High body temperature
- Clinical Presentation & Variations
- Presentation/Transfusion Dyspnea Shock Hhypoxia
- Disease Progression
- Course/Catastrophic presentation/onset
- Course/Fulminant/Precipitous
- Course/Lethal possible/not usual
- Prognosis/Recovery/reversable usually
- Demographics & Risk Factors
- Exposure Factors
- Exposure/Specific blood donor
- Established Disease Population
- Patient/Chemotherapy/cancer
- Patient/Blood transfusion/recent
- Population Group
- Population/Hospital patient
- Occupational Factors
- Setting/Hospital setting
- Setting/Intensive/postop/cardiac care unit
- Laboratory Tests
- Abnormal Lab Findings (Non Measured)
- Acute inflammatory markers elevated (Lab)
- Abnormal Lab Findings - Decreased
- Arterial Hgb O2 saturation (Lab)
- Platelet count (Lab)
- Abnormal Lab Findings - Increased
- Isohemagglutinin titers (Lab)
- Lactic Dehydrogenase (LDH LH) (Lab)
- Neutrophile/Leukoagglutinins Antibody Test
- Diagnostic Test Results
- X-RAY
- Xray/Chest abnormal
- Xray/Bilateral pulmonary infiltrates/Chest
- Xray/Chest/Lung fields/Abnormal
- Xray/Generalized alveolar disease/Chest
- Xray/Infiltrate, pulmonary/Chest
- Xray/Interstitial infiltrate, acute/Chest
- Xray/Pneumonitis/pattern no infection/Chest
- Xray/Whiteout/lung fields/Chest
- Associated Diseases & Rule outs
- Rule Outs
- Amniotic fluid embolism
- Cardiogenic Pulmonary Edema
- Disseminated intravascular coagulation
- Pneumonia
- Pneumonia, bacterial
- Pneumonia, interstitial, acute
- Pneumonia, viral
- Pneumonia/Bronchopneumonia
- Pulmonary edema
- Pulmonary edema/acute left vent failure
- Pulmonary embolism
- Transfusion/anaphylaxis foreign protein reaction
- Associated Disease & Complications
- Blood transfusion/misadventure
- Hypotension
- Hypoxia, systemic
- Pulmonary edema/non-cardiogenic
- Respiratory distress (adult) syndrome
- Respiratory failure/Pulmonary insufficiency
- Shock
- Transfusion reaction
- Transfusion Related Acute Lung Injury
- Disease Mechanism & Classification
- Class
- CLASS/Immune System Disorder (ex)
- CLASS/Alveolar disorder
- CLASS/Pulmonic (category)
- Pathophysiology
- Pathophysiology/Donor Blood Multip Female/HLA2
- Pathophysiology/Activated complement cascade/effect
- Pathophysiology/Alveolar leukocyte invasion/kinin release
- Pathophysiology/Alveolar macrophage malfunction
- Pathophysiology/Alveolar wall destruction
- Pathophysiology/Anti-Recipient Neutrophile Antibodies
- Process
- PROCESS/Allergy/collagen/autoimmune (category)
- PROCESS/Complicating disorder (ex)
- PROCESS/Iatrogenic (category)
- PROCESS/INCIDENCE/Rare disease (ex)
- PROCESS/Inflammatory/Allergy/immune (ex)
- PROCESS/Transfusion reaction (ex)
- PROCESS/Immune system disorder (ex)
- PROCESS/Immune/antibody-antigen system dis. (ex)
- Synonyms
- Synonym
- TRALI, Transfusion related acute lung injury, Transfusion related acute lung injury (disorder), Synonym/Allergic pulmonary edema/TRALI synd, Synonym/Leukoagglutinin pulmonary reaction, Synonym/Pulmonary hypersensitivity reaction/TRALI synd, Synonym/TRALI syndrome, Synonym/Transfusion hypersensitivity lung syndrome
- Treatment
- Drug Therapy - Contraindication
- RX/Blood transfusion/packed cells
- RX/Diuretic
- Drug Therapy - Indication
- RX/Oxygen
- Surgical Procedures or Treatments
- TX/Rest-Time off
- Other Treatments
- TX/Expectant/supportive treatment.
- TX/Intensive care management
- TX/Intubation/ventilation assist.
- TX/Ventilation Assist IPPB
- Definition
-
Immune reaction usually to transfusion of allogenic leukocyte antibodies in plasma from donor often with fresh frozen plasma; reaction is at alveolocapillary level; this causes acute hypoxia and often goes on to ARD; donor should be excluded in future; occurs 1 to 2 hours after transfusion; with no hemolysis; anti-hla or granulocyte antibodies in donor 87% of time; restrict donor support patient; question steroid treatment, never diuretics
(Edit)
- External Links Related to Transfusion Related Acute Lung Injury/TRALI syndrome
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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