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Disease Information for Tolbutamide (Orinase) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Hyperhidrosis/Chronic sweating excess

Rash

Sweating Excess Perspiration

Bone Pain Triggered by Alcohol

Laboratory Tests

Abnormal Lab Findings - Decreased

Neutrophiles (Lab)

Triglycerides (Lab)

Abnormal Lab Findings - Increased

Glucose, blood (Lab)

Associated Diseases & Rule outs

Associated Disease & Complications

Cholestasis/intrahepatic biliary obstruction

Cholestatic Jaundice Syndrome

Drug induced Cholestasis hepatitis

Drug induced Hypoglycemia

Drug induced Inappropriate ADH syndrome/SIADHS

Drug induced Neutropenia.

Drug induced Photosensitivity rash

Drug rash/Drug induced rash

Granulocytopenia/Neutropenia

Hypoglycemia

Obstructive jaundice syndrome

Photosensitivity dermatitis

Phototoxicity

Porphyria, attack, acute intermittant

Sulfonamide allergy

Toxic hepatitis

Disease Mechanism & Classification

Drugs

DRUG/Anti-diabetic medication (example)

DRUG/Dangerous for kids (10Kg)/Very

DRUG/Stimulates pancreatic insulin release

DRUG/Sulfonylurea antidiabetic medication (ex0

Synonyms

Synonym

Benzenesulfonamide N ((butylamino)carbonyl) 4 methyl, Tolbutamide, Tolbutamide (product), Tolbutamide (substance), TOLBUTAMIDE PREPARATION, Brand name/Orinase (Tolbutamide)

Treatment

Drug Therapy - Contraindication

RX/Warfarin (Coumadin)

Drug Therapy - Indication

RX/Diazoxide (Hyperstat)

RX/Octreotide (Sandostatin)

Drug Dosage

DRUG/Oral medication (ex)

Definition

Anti-diabetic hypoglycemic drug. Sulfonylurea islet cell stimulation and pancreatic insulin release.Type II diabetic treatment. Oral medication.

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External Links Related to Tolbutamide (Orinase) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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