Disease Information for Thrombocythemia, essential

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Clinical Manifestations
Signs & Symptoms
Purpura
Bleeding gums
Acroparesthesias Acral Paresthesias
Fatigability
Headache
Headache, throbbing, vascular
Paresthesias
Stroke syndrome/signs
Tingling lips/hands/paresthesias
Epistaxis, severe/persistent
Chronic Fatigue
Fatigue
Fatigue Tiredness Exhaustion
Disease Progression
Course/Acute
Course/Chronic disorder
Demographics & Risk Factors
Established Disease Population
Patient/Polycythemia vera
Laboratory Tests
Abnormal Lab Findings (Non Measured)
JAK-2 Kinase/Gene Marker (Janus family)
Cytogenetics/JAK-2V617F Mutation
Blood smear/platelets clumped (Lab)
Abnormal Lab Findings - Increased
Leukocyte Alkaline phosphatase (Lab)
Mean Platelet Volume (MPV)
Platelet count (Lab)
Potassium, serum (Lab)
Diagnostic Test Results
Pathology
PATH/White thrombi microvascular infarcts
Associated Diseases & Rule outs
Rule Outs
Acute leukemia
Antiphospholipid Syndrome/APLS
Associated Disease & Complications
Abortion, habitual (spontaneous,recurrent)
Acute Superior Mesenteric Artery Blockage
Adrenal hemorrhage
Alveoloproteinosis, pulmonary
Bone Marrow Fibrosis
Cerebral ischemia
Cerebral thrombosis
Cerebral vascular accident
CVA Hematologic disorders/Cause
CVA Vascular disorders causes
Epistaxis/nosebleed
Erythromelalgia
Hemarthrosis
Hepatic nodular regeneration/hyperplastic dif
Hepatic vein thrombosis (Budd-Chiari)
Hypercoagulability/Thrombophilia
Hyperkalemia
Iron deficiency anemia
Livedo reticularis
Massive pulmonary embolism
Mesenteric artery thrombosis
Mesenteric vein thrombosis
Myelofibrosis
Myelogenous leukemia, chronic
Myeloproliferative disorder
Myocardial infarction, acute
Peptic ulcer hemorrhage
Phlegmasia cerulea dolens
Polycythemia vera
Portal vein thrombosis
Pulmonary embolism
Pulmonary infarction
Raynaud's syndrome
Renal vasculitis
Retinal vein thrombosis, central
Splenic infarction
Stroke/Child
Thrombocythemia, essential
Thrombocytosis
Thrombocytosis in Elderly
Thromboembolic disease
Thrombophlebitis Arm/Deep Vein
Thrombophlebitis, deep vein
Thrombosis, renal vein
Transient ischemic attack/cerebral
Vertebrobasilar artery insufficiency
Hyperviscosity
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Platelet disorder (ex)
Pathophysiology
Pathophysiology/JAK-2/V16F Gene mutation
Pathophysiology/Malignant deterioration/progression/potential
Pathophysiology/Premalignant risk
PROCESS/Thrombotic Microangiopathy
Pathophysiology/Myocardial Ischemia Non-Arteriosclerosis
Pathophysiology/Thrombotic microangiopathy/TMA
Process
PROCESS/Neoplastic (category)
PROCESS/Reference organ/system (category)
PROCESS/Blood dyscrasia/leukemic process (ex)
PROCESS/Leukemia process (ex).
Treatment
Drug Therapy - Indication
RX/Anagrelide (Agrylin)
RX/Anticoagulants
RX/Aspirin (Acetylsalicylic acid)
RX/Chemotherapy(cancer)
RX/Hydroxyurea (Hydrea)
RX/Interferon alpha
Other Treatments
TX/Cytapheresis/technique
TX/Platelet-pheresis.
Definition

A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.

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External Links Related to Thrombocythemia, essential
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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