Disease Information for Thoracic neuroblastoma

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Clinical Manifestations
Signs & Symptoms
Acute Chest Pain in Children
Chest Pain
Chest Pain in Children
Back Pain
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Children/all
Laboratory Tests
Abnormal Lab Findings - Increased
URINE Catecholamines
URINE Metanephrines
Diagnostic Test Results
Isotope Scan
Isotope/MIBG I131 scan abnormal (metaiodobenzylguanidine)
CT Scan
MRI/Chest abnormal
X-RAY
Xray/Chest abnormal
Xray/Calcifications apparent/Chest
Xray/Chest film/extrapulmonary abnormal
Xray/Chest/Lung fields/Abnormal
Xray/Mediastinal mass/Chest
Xray/Posterior calcified mass on rib/Chest
Xray/Wide mediastinum/Chest
Xray/Ribs inferior bone resorption
Xray/Ribs, notching margins
Associated Diseases & Rule outs
Rule Outs
Lymphoma/Malignant lymphoma
Associated Disease & Complications
Chylous pleural effusion
Retroperitoneal tumor
Disease Mechanism & Classification
Class
CLASS/Midline structures/disorders (ex)
CLASS/Neurologic (category)
CLASS/Pulmonic (category)
Pathophysiology
Pathophysiology/Gene locus 1q21
Process
PROCESS/Benign tumor (ex).
PROCESS/Neoplastic (category)
Definition

Neuroblastomas are neural tumors and abnormalities that have cell origins from the neural crest; ICD-9CM CODES; 194_0 Neuroblastoma, unspecified site; 8% of all solid tumors of childhood; Male >female ratio Childhood; Infants and children; N-myc protooncogene; loss of short arm chromosome 1 (1p36) found in some children; CLINICAL: Mass in abdomen, neck, or chest or head; Spinal cord compression; Dancing eyes; Chronic pain; Ecchymosis around eyes; Weight loss; Fever; DIFFERENTIAL: Other childhood tumors; Wilms’ tumor; Diagnosis: Biopsy of tumor; Urinary catecholamines; Bone marrow aspiration; CT scan or MRI abdomen/chest;hope for recovery with aggressive treatment ;Surgery; Multiagent chemotherapy (eg, cyclophosphamide, vincristine, dacarbazine, melphalan, doxorubicin, cisplatin); Radiotherapy ;either death or cure ;Overall survival is >40%Survival in stage I is >95%, whereas survival in stage II is <20% [Evans classification];----------[Ferri"s Clinical advisor 2005]--

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External Links Related to Thoracic neuroblastoma
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Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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