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Disease Information for Thoracic neuroblastoma

Clinical Manifestations

Signs & Symptoms

Acute Chest Pain in Children

Chest Pain

Chest Pain in Children

Back Pain

Disease Progression

Course/Chronic disorder

Course/Chronic only

Demographics & Risk Factors

Population Group

Child

Population/Pediatrics population

Sex & Age Groups

Population/Child

Population/Children/all

Laboratory Tests

Abnormal Lab Findings - Increased

URINE Catecholamines

URINE Metanephrines

Diagnostic Test Results

Isotope Scan

Isotope/MIBG I131 scan abnormal (metaiodobenzylguanidine)

CT Scan

MRI/Chest abnormal

X-RAY

Xray/Chest abnormal

Xray/Calcifications apparent/Chest

Xray/Chest film/extrapulmonary abnormal

Xray/Chest/Lung fields/Abnormal

Xray/Mediastinal mass/Chest

Xray/Posterior calcified mass on rib/Chest

Xray/Wide mediastinum/Chest

Xray/Ribs inferior bone resorption

Xray/Ribs, notching margins

Associated Diseases & Rule outs

Rule Outs

Lymphoma/Malignant lymphoma

Associated Disease & Complications

Chylous pleural effusion

Retroperitoneal tumor

Disease Mechanism & Classification

Class

CLASS/Midline structures/disorders (ex)

CLASS/Neurologic (category)

CLASS/Pulmonic (category)

Pathophysiology

Pathophysiology/Gene locus 1q21

Process

PROCESS/Benign tumor (ex).

PROCESS/Neoplastic (category)

Definition

Neuroblastomas are neural tumors and abnormalities that have cell origins from the neural crest; ICD-9CM CODES; 194_0 Neuroblastoma, unspecified site; 8% of all solid tumors of childhood; Male >female ratio Childhood; Infants and children; N-myc protooncogene; loss of short arm chromosome 1 (1p36) found in some children; CLINICAL: Mass in abdomen, neck, or chest or head; Spinal cord compression; Dancing eyes; Chronic pain; Ecchymosis around eyes; Weight loss; Fever; DIFFERENTIAL: Other childhood tumors; Wilms’ tumor; Diagnosis: Biopsy of tumor; Urinary catecholamines; Bone marrow aspiration; CT scan or MRI abdomen/chest;hope for recovery with aggressive treatment ;Surgery; Multiagent chemotherapy (eg, cyclophosphamide, vincristine, dacarbazine, melphalan, doxorubicin, cisplatin); Radiotherapy ;either death or cure ;Overall survival is >40%Survival in stage I is >95%, whereas survival in stage II is <20% [Evans classification];----------[Ferri"s Clinical advisor 2005]--

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External Links Related to Thoracic neuroblastoma

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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