Disease Information for Thiothixene (Navane) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Orthostatic drop in blood pressure
Impotence, relative
Spontaneous ejaculation
Dry mouth/Mucous membranes
Motor restlessness
Akathisia
Athetosis
Choreoathetoid movement
Dystonia, acquired
Odd body posturing
Seizures
Stupor/poor reponse to stimulus
Tremor
Unable to sit still/restlessness
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Hyperprolactinemia
Abnormal Lab Findings - Increased
Prolactin (Lab)
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Convulsions (grand mal)
Drug induced Acute dystonia reaction
Drug Induced Choreoathetosis
Drug induced Impotence.
Drug induced Inappropriate ADH syndrome/SIADHS
Drug induced Movement disorder
Drug induced Orthostatic hypotension
Impotence/Erectile dysfunction disorder
Neuroleptic malignant syndrome
Orthostatic hypotension syndrome
Orthostatic syncope Hypotension
Parkinsonism, secondary
Sedation/torpor induced
Tardive dyskinesia syndrome
Urinary bladder retention
Disease Mechanism & Classification
Drugs
DRUG/Antipsychotic/neuroleptic drug (example)
DRUG/Anti-Schizophrenia medication (example)
DRUG/Phenothiazine class drug (example)
DRUG/Psychoactive/sedative drug (category)
DRUG/Lowers seizure threshold
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
9H Thioxanthene 2 sulfonamide N,N dimethyl 9 (3 (4 methyl 1 piperazinyl)propylidene), N,N Dimethyl 9 (3 (4 methylpiperazin 1 yl)propylidene) 9H thioxanthene 2 sulphonamide, Navaron, Orbinamon, P 4657 B, THIOTHIXENE, Thiothixene (product), Thiothixene (substance), THIOTHIXENE PREPARATION, Thioxanthene 2 sulfonamide N,N dimethyl 9 (3 (4 methyl 1 piperazinyl)propylidene), Tiotixene, Brand name/Navane (Thiothixene)
Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral drug; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

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External Links Related to Thiothixene (Navane) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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