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Disease Information for Thalidomide (Thalomid) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Blood in stool

Dark/Black Melena Stool

Hematochezia/Blood per Rectum

Stool color/appearance abnormal

Associated Diseases & Rule outs

Associated Disease & Complications

Cleft Lip

Cleft lip/deformity

Cleft palate/deformity

Drug induced Peripheral neuropathy.

Fetal anomaly

Fetal damage/teratogenic effect

Limb deformities/anomalies

Peripheral neuropathy

Phocomelia

Polyneuritis

Toxic peripheral/polyneuropathy

Polyneuropathy

Hand anomalies

Disease Mechanism & Classification

Drugs

DRUG/Anti-angiogenesis medication

DRUG/Anti-leprosy antibiotic (example)

DRUG/Antimicrobic types of drug/classes (example)

DRUG/Immune modulator drug (ex)

DRUG/Teratogenic potential/effect (D plus )

DRUG/Teratogenic/OBGYN Class X/Pregnancy DANGER

DRUG/Fetal anomalies via father/sperm

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

( ) Thalidomide, (+) Thalidomide, 1H Isoindole 1,3(2H) dione 2 (2,6 dioxo 3 piperidinyl), 2 (2,6 Dioxo 3 piperidinyl) 1H isoindole 1,3(2H) dione, 2 6 Dioxo 3 phthalimidopiperidine, 2,6 Dioxo 3 phthalimidopiperidine, 3 Phthalimidoglutarimide, Alpha Phthalimidoglutarimide, N (2,6 Dioxo 3 piperidyl)phthalimide, N Phthaloylglutamimide, N Phthalylglutamic Acid Imide, Phthalimide N (2 6 dioxo 3 piperidyl) ( ), Phthalimide N (2 6 dioxo 3 piperidyl) (+), Sedalis, THAL, Thalidomide, Thalidomide chemical, Thalidomide chemical (substance), Thalidomide (product), Thalidomide (substance), THALIDOMIDE PREPARATION, Brand name/Thalomid (Thalidomide)

Treatment

Drug Dosage

DRUG/.$$$$$ Most Expensive

DRUG/Dose 50 mgm (Unit/Pill/Capsule size)

DRUG/Dose Hour of sleep/HS medication

DRUG/Drug discontinued/TOXIC (RX)

Definition

Immunosuppressant novel drug; Anti-angiogenesis and VERY teratogenous drug used in leprosy and cancer chemotherapy including multiple myeloma; strict protocol control by manufacturer; oral preparation

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External Links Related to Thalidomide (Thalomid) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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