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- Disease Information
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Disease Information for Terfenadine (Seldane) Toxicity
- Clinical Manifestations
- Signs & Symptoms
- Tachycardia/Fast heart rate
- Diagnostic Test Results
- EKG (ECG)
- EKG/Drug induced QT prolongation (ECG)
- EKG/Prolonged QT interval (ECG)
- Associated Diseases & Rule outs
- Associated Disease & Complications
- Cardiac arrhythmias
- Drug induced Arrhythmias
- Drug induced Prolonged Q-T interval
- Torsades de pointes/ventricular tachycardia
- Ventricular fibrillation
- Ventricular tachycardia
- Ventricular tachycardia/arrest
- Disease Mechanism & Classification
- Drugs
- DRUG/Antihistamine medication (examples)
- DRUG/Cytochrome CY P450 3A4 degradation pathway
- DRUG/P450 metabolic pathway/competitor
- Process
- PROCESS/Medication/Drug (CONFIRM dose/before treatment)
- Synonyms
- Synonym
- 1 Piperidinebutanol alpha (4 (1,1 dimethylethyl)phenyl) 4 (hydroxydiphenylmethyl), alpha (4 (1,1 Dimethylethyl)phenyl) 4 (hydroxydiphenylmethyl) 1 piperdinebutanol, terfenadine, Terfenadine (product), Terfenadine (substance), TERFENADINE PREPARATION, Terfenadine product, Terfenidine, Brand name/Seldane (Terfenadine)
- Definition
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Antihistamine drug; Non-sedating class of drug; declared TOXIC and withdrawn from market because of frequent torsade de pointes ventricular arrhythmias with other drugs sharing P450 metabolic pathways
(Edit)
- External Links Related to Terfenadine (Seldane) Toxicity
- Wikipedia
- Merck
- Images
- PubMed (National Library of Medicine)
- NGC (National Guideline Clearinghouse)
- Medscape (eMedicine)
- Harrison's Online (accessmedicine)
- NEJM (The New England Journal of Medicine)
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