Disease Information for Terfenadine (Seldane) Toxicity

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Clinical Manifestations
Signs & Symptoms
Tachycardia/Fast heart rate
Diagnostic Test Results
EKG (ECG)
EKG/Drug induced QT prolongation (ECG)
EKG/Prolonged QT interval (ECG)
Associated Diseases & Rule outs
Associated Disease & Complications
Cardiac arrhythmias
Drug induced Arrhythmias
Drug induced Prolonged Q-T interval
Torsades de pointes/ventricular tachycardia
Ventricular fibrillation
Ventricular tachycardia
Ventricular tachycardia/arrest
Disease Mechanism & Classification
Drugs
DRUG/Antihistamine medication (examples)
DRUG/Cytochrome CY P450 3A4 degradation pathway
DRUG/P450 metabolic pathway/competitor
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 Piperidinebutanol alpha (4 (1,1 dimethylethyl)phenyl) 4 (hydroxydiphenylmethyl), alpha (4 (1,1 Dimethylethyl)phenyl) 4 (hydroxydiphenylmethyl) 1 piperdinebutanol, terfenadine, Terfenadine (product), Terfenadine (substance), TERFENADINE PREPARATION, Terfenadine product, Terfenidine, Brand name/Seldane (Terfenadine)
Definition

Antihistamine drug; Non-sedating class of drug; declared TOXIC and withdrawn from market because of frequent torsade de pointes ventricular arrhythmias with other drugs sharing P450 metabolic pathways

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External Links Related to Terfenadine (Seldane) Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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