Disease Information for T-cell leukemia

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Clinical Manifestations
Signs & Symptoms
Lymphadenopathy
Lymphadenopathy Systemic
Hepatosplenomegaly
Palpable Liver/Hepatomegaly
Fatigability
Recurrent URI/Colds/LRI infections
Splenomegaly
Chronic Fatigue
Enervated/extreme acute fatigue
Fatigue
Fatigue Tiredness Exhaustion
Fatigue Tiredness in Elderly
Fever
Fever Febrile Possible
Fever in elderly
Fevers, low grade/recurrent
Flu-Like Syndrome
High body temperature
Clinical Presentation & Variations
Presentation/Recurrent Infections
Fever and High Sed Rate
Disease Progression
Course/Chronic disorder
Course/Chronic only
Course/Prognosis good/usually
Demographics & Risk Factors
Ethnic or Racial Factors
Population Caucasian/White
Population Group
Aged Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Population/Elderly Aged
Population/Seventies Adult
Population/Sixties-adult
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Cytogenetics Abnormal
Acute inflammatory markers elevated (Lab)
Flow cytometry tests/abnormal (Lab)
Helper/suppressor T-cell ratio decreased (Lab)
Right Shift (Viral) Differential Smear (Lab)
Abnormal Lab Findings - Decreased
Hematocrit (Lab)
Hemoglobin (Lab)
Neutrophiles (Lab)
Platelet count (Lab)
RBC/Red Blood Count (Lab)
Abnormal Lab Findings - Increased
Calcium, serum (Lab)
CD4 Helper cells (Lab)
Lymphocytes (Lab)
Monocytes (Lab)
Sed Rate/ESR/Sedimentation rate (Lab)
T-cell/T8/suppressor cell (Lab)
Diagnostic Test Results
Other Tests & Procedures
Flow Cytometry/CD3 CD4 antigens
Flow Cytometry/CD3 CD4 CD25 antigen
Flow Cytometry/CD7 pan-T helper cell antigen
Pathology
BX/Skin Upper dermis T cell infiltration
Associated Diseases & Rule outs
Associated Disease & Complications
Abscess, perianal/pararectal
Anemia
Cyclic neutropenia
Granulocytopenia/Neutropenia
Hypercalcemia
Lymphocytosis
Lymphoproliferative disorder
Mycosis fungoides
T-cell leukemia
Disease Mechanism & Classification
Specific Agent
Microlab/HLTV1 (Lymphotropic virus, human I) Present
Class
CLASS/Lymphocyte disorder (ex)
Pathophysiology
Pathophysiology/Gene locus 11p13
Pathophysiology/Gene locus Chromosome 6
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Process
PROCESS/Ethnic predilection (ex)
PROCESS/Neoplastic (category)
PROCESS/Blood dyscrasia/leukemic process (ex)
PROCESS/Leukemia process (ex).
PROCESS/Lymphoproliferative disorder (ex)
Synonyms
Synonym
Acute T Cell Leukemia, Acute T Cell Leukemias, Acute T Cell Lymphoblastic Leukemia, Acute T Cell Lymphocytic Leukemia, Acute T Lymphocytic Leukemia, Acute T Lymphocytic Leukemias, Cortical T ALL, Leukemia Acute T Cell, Leukemia Acute T Lymphocytic, Leukemia Lymphoblastic Acute T Cell, Leukemia Lymphocytic Acute T Cell, Leukemia T Cell Acute, Leukemias Acute T Cell, Leukemias Acute T Lymphocytic, Lymphoblastic Leukemia Acute T Cell, LYMPHOCYTIC LEUKEMIA ACUTE BT, Lymphocytic Leukemia T Cell Acute, Pre T ALL, Precursor T cell lymphoblastic leukaemia, Precursor T cell lymphoblastic leukemia, Precursor T cell lymphoblastic leukemia (morphologic abnormality), Precursor T Lymphoblastic Leukemia, Pro T ALL, T ALL, T cell acute lymphobl leukaem, T cell acute lymphoblastic leukaemia, T Cell Acute Lymphoblastic Leukemia, T cell acute lymphoblastic leukemia (disorder), T Cell Leukemia Acute, T Cell Leukemias Acute, T cell lymphoblastic leukaemia acute, T cell lymphoblastic leukemia acute, T cell type acute leukaemia, T cell type acute leukemia, T Lymphocytic Leukemia Acute, T Lymphocytic Leukemias Acute, Synonym/Large granular lymphocytic leukemia, Synonym/T8 Hyperlymphocytosis, Synonym/T-cell lymphocytosis/with neutropenia, Synonym/T-suppressor/CLL
Treatment
Drug Therapy - Indication
RX/Alkylating agents
RX/Chemotherapy(cancer)
RX/Nelarabine (Arronon)
RX/Pentostatin/Deoxycoformycin (DCF) Nipentin
Other Treatments
TX/Expectant/supportive treatment.
Definition

A subtype of lymphocytic leukemia classified as acute or chronic depending on the degree of cell differentiation, not the duration of the disease.

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External Links Related to T-cell leukemia
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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