Disease Information for Status epilepticus

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Clinical Manifestations
Signs & Symptoms
Tachycardia/Fast heart rate
Piloerection/goosebumps sign/skin
Bowel/Stool Incontinence
Stroke syndrome/signs
Urine Incontinence
Acutely ill patient/signs
Compliance failures/Patient issues
Fever
Fever Febrile Possible
Fever, high
Flu-Like Syndrome
High body temperature
Clinical Presentation & Variations
Presentation/High Temperature No Infection
Disease Progression
Course/Acute
Course/Acute only
Course/Catastrophic presentation/onset
Course/Eventual terminal event/death possible
Course/Potentially lethal/untreated
Lethal Potential
Demographics & Risk Factors
Established Disease Population
Patient/Epilepsy
Occupational Factors
Setting/Intensive/postop/cardiac care unit
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
CPK Extreme levels/MB fraction < 5" (Lab)
Transaminase elevation (Lab)
Very High CPK
Abnormal Lab Findings - Decreased
Lactic acid/Lactate (Lab)
pO2, arterial blood (Lab)
Abnormal Lab Findings - Increased
Aldolase, serum (Lab)
ALT (SGPT) (Alanine transferase) (Lab)
Anion gap (Lab)
Aspartamine aminotransferase (SGOT, AST) (Lab)
AST (SGOT) (aspartamine transferase) (Lab)
Carbon Dioxide Total Content/CO2
CK-MM (Lab)
CPK/CK/Creatine kinase/Creatine phosphokinase (Lab)
Glucose, blood (Lab)
Lactic acid/Lactate (Lab)
Lactic Dehydrogenase (LDH LH) (Lab)
PCO2, arterial blood (Lab)
pH, arterial blood (Lab)
Phosphate Serum (Lab)
Potassium, serum (Lab)
URINE Myoglobin
Diagnostic Test Results
Other Tests & Procedures
Lumbar puncture/Increased CSF pressure/LP test
Electrodiagnosis
EEG/Seizure activity abnormality
Pulse oximetry/low O2 saturation
Associated Diseases & Rule outs
Rule Outs
Cerebral vascular accident
Coma/Unconscious
Eclampsia of pregnancy
Tetanus
Associated Disease & Complications
Acidosis
Acidosis, metabolic
Acute Tubular Necrosis
Anal Incontinence
Apnea
Aspiration
Death Outcome
Death/Unanticipated
Encephalopathy/postanoxic
Hypercapnea Hypercarbia
Hyperglycemia
Hyperkalemia
Hyperphosphatemia
Hyperpyrexia
Hyperthermia
Hypoglycemia
Hypoxemia
Hypoxia, systemic
Lactic acidosis
Metabolic Acidosis with High Anion Gap
Myoglobinuria
Pneumonia, aspiration
Pulmonary edema/non-cardiogenic
Respiratory failure/Pulmonary insufficiency
Rhabdomyolysis
Seizure disorder (epilepsy)
Status epilepticus
Disease Mechanism & Classification
Class
CLASS/Neurologic (category)
Pathophysiology
Pathophysiology/Excess heat production
Pathophysiology/Uncontrolled muscle contraction
Pathophysiology/CSF Pressure Increased
Pathophysiology/Epileptiform/epileptic disorder
Pathophysiology/Lung Ventilation Neuromuscular
Process
PROCESS/Complicating disorder (ex)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Treatment
Drug Therapy - Indication
RX/Anticonvulsants
RX/Barbiturate
RX/Diazepam (Valium)
RX/Diazepam (Valium) injection (acute)
RX/Lorazepam (Ativan)
RX/Midazolam (Versed)
RX/Pentobarbital (Nembutal)
RX/Phenobarbital
RX/Phenytoin
RX/Sedation
Other Treatments
TX/General anesthesia/as treatment.
TX/Intensive care management
TX/Medical emergency
TX/Restraint
Definition

A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes; The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction; Some are in COMA status with Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances; Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition ( EPILEPSIA PARTIALIS CONTINUA); Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity-----(From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)-----------

Common in ICU/CCU patients especially in hypoxic CNS injury, those with remote seizure history, and evident ocular movement abnormalities; treatment is usually Lorazepam or other Benzodiazepines; This can be a lethal disorder

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External Links Related to Status epilepticus
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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