Disease Information for Spironolactone (Aldactone) Administration/Toxicity

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Clinical Manifestations
Signs & Symptoms
Breast Swelling Bilateral
Galactorrhea/Male
Lactorrhea in a male
Lactorrhea/Galactorrhea/Prolonged lactation
Impotence, relative
Disease Progression
Galactorrhea
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Normal Anion Gap Acidosis
Abnormal Lab Findings - Decreased
Androgens (Lab)
Testosterone Total (Lab)
URINE Aldosterone
Abnormal Lab Findings - Increased
LH/Leutinizing Hormone (Lab)
Potassium, serum (Lab)
URINE Leutininzing hormone
Associated Diseases & Rule outs
Associated Disease & Complications
Acidosis
Acidosis, metabolic
Drug induced Hyperkalemia
Drug induced Impotence.
Gynecomastia
Hyperchloremic metabolic acidosis
Hyperkalemia
Hypogonadism, male
Impotence/Erectile dysfunction disorder
Pseudohypoaldosteronism
Renal tubular acidosis/type IV
Disease Mechanism & Classification
Drugs
DRUG/Aldosterone antagonist/Spironolactone congener
DRUG/Anti-acne medication (example)
DRUG/Anti-androgen drug (example)
DRUG/Anti-androgen effect
DRUG/Dermatology use
DRUG/Diuretic medication (example)
DRUG/Diuretic/potassium sparing (example)
DRUG/Incidental anti-androgen/hirsuitism medication (ex)
DRUG/Teratogenic potential/effect (D plus )
DRUG/Unction/ointment/gel dermatologic application
Pathophysiology
Pathophysiology/Secondary Testicular Failure
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
17 Hydroxy 7alpha mercapto 3 oxo 17alpha pregn 4 ene 21 carboxylic Acid gamma Lactone Acetate, Pregn 4 ene 21 carboxylic acid 7 (acetylthio) 17 hydroxy 3 oxo gamma lactone (7alpha,17alpha), Spirolactone, SPIRONOLACTONE, Spironolactone (product), Spironolactone (substance), SPIRONOLACTONE PREPARATION, SPL, Veroshpiron, Verospirone, Brand name/Aldactazide (Spironolactone-HCZ) combination), Brand name/Aldactone (Spironolactone)
Treatment
Drug Therapy - Contraindication
RX/Triamterene (Dyrenium)
Drug Dosage
DRUG/Dose 100 mgm (Unit/Pill/Capsule size)
DRUG/Dose 25 mgm (Unit/Pill/Capsule size)
DRUG/Dose 50 mgm (Unit/Pill/Capsule size)
DRUG/Dose BID Medication
DRUG/Generic available
DRUG/Oral medication (ex)
Definition

Potassium sparing diuretic;synthetic anti-aldosterone receptor medication often used in combination with thiazide;oral preparation

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External Links Related to Spironolactone (Aldactone) Administration/Toxicity
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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