Disease Information for Sideroblastic Anemia Siderochrestic

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Clinical Manifestations
Signs & Symptoms
Anemia symptoms/chronic
Mucous membrane pallor
Pallor
Conjunctival pallor
Clinical Presentation & Variations
Presentation/Anemia Refractory
Disease Progression
Course/Chronic disorder
Course/Chronic only
Onset/insidious
Demographics & Risk Factors
Past History
Past history/Refractory anemia
Family History
Family history/Anemia
Sex & Age Groups
Population/Adult Aged Only
Population/Adult/all
Laboratory Tests
Microbiology & Serology Findings
Reticulocytosis
Abnormal Lab Findings (Non Measured)
Cytogenetics Abnormal
Dimorphic RBC/smear/normochomic/hypochromic (Lab)
Flow cytometry tests/abnormal (Lab)
Free erythrocyte protoporphrin/FEE test positive (Lab)
Indirect bilirubin inc/normal direct bil. (Lab)
Microcytes/small RBCs on Blood smear
Microcytosis/microcytic anemia (Lab)
RBC/Pappenheimer Bodies Smear
Abnormal Lab Findings - Decreased
WBC
Cholesterol (Lab)
Folic acid/Folate (Lab)
Hematocrit (Lab)
Hemoglobin (Lab)
Leukocyte Alkaline phosphatase (Lab)
MCH (Lab)
MCHC (Lab)
MCV/Mean Corpuscular Volume (Lab)
Neutrophiles (Lab)
Osmotic fragility, RBC (Lab)
Platelet count (Lab)
RBC/Red Blood Count (Lab)
Reticulocytes (Lab)
TIBC/Total Iron Binding capacity (Lab)
WBC/White Blood Cell Count/Leukocytes (Lab)
Abnormal Lab Findings - Increased
Anisocytosis (Lab)
Basophilic stippling, RBC (Lab)
Bilirubin, serum (Lab)
Coproporphyrin RBC (Lab)
Ferritin, serum (Lab)
Indirect bilirubin (Lab)
Iron, serum (Lab)
Monocytes (Lab)
Platelet count (Lab)
Poikilocytes (Lab)
Protoporphyrin RBC (Lab)
Protoporphyrin (Lab)
RDW/Red cell size variance (Lab)
Siderocytes (Lab)
Transferrin (Lab)
Transferrin saturation (Lab)
Zinc Protoporphyrin/RBC (Lab)
Diagnostic Test Results
Pathology
Bone Marrow/Abnormal
Bone Marrow/Erythroid hyperplasia
Bone marrow/Iron loaded paranuclear mitochondria/Fe stain
Bone Marrow/Iron stores/increased
Bone marrow/Ringed sideroblasts/Fe stain
BX/Bone Marrow Biopsy/Abnormal
Isotope Scan
Isotope/Ferrokinetic study/abnormal
Associated Diseases & Rule outs
Rule Outs
Hemochromatosis
Iron deficiency anemia
Associated Disease & Complications
Acute Myelocytic/Monocytic Leukemia
Acute Myelogenous/Myeloblastic Leukemia AML
Anemia
Bilirubinemia
Congestive heart failure
Hemosiderosis
Leukemia
Megaloblastic anemia/disease
Sideroblastic Anemia Sideroachrestic
Thrombocytosis
Anemia in Elderly
Iron Overload
Disease Mechanism & Classification
Class
CLASS/Primary organ/system disorder (ex)
CLASS/Erythrocyte disorder (ex)
CLASS/Hematologic (category)
Pathophysiology
Pathophysiology/Bimodal RBC size distribution
Pathophysiology/Gene locus Chromosome X.
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Gene locus Xp11.21
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Perinuclear mitochondrial iron overload/normoblasts
Pathophysiology/Failed hemoglobin/protoporphyrin/incorp
Pathophysiology/Ineffective erythropoesis
Pathophysiology/Marrow iron store high/poor release
Process
PROCESS/Idiopathic/unclassified/unknown (category)
PROCESS/Reference organ/system (category)
Treatment
Drug Therapy - Indication
SX/Stem cell transplant/allogenic
SX/Stem-cell transplant
Definition

Sideroblastic: Acquired Sideroblastic Anemia; Hereditary Sideroblastic Anemia; Idiopathic Sideroblastic Anemia;

The sideroblastic anemias are a group of blood disorders in which the body has enough iron but is unable to use it to make hemoglobin, which carries oxygen in the blood; As a result, iron accumulates in the mitochondria of red blood cells, giving a ringed appearance to the nucleus (ringed sideroblast); There are three categories of sideroblastic anemias: inherited, acquired, and idiopathic (of unknown origin); The signs and symptoms can range from mild to severe, and include fatigue, breathing difficulties, and weakness; Enlargement of the liver or spleen may also occur; In severe cases, the increased levels of iron in the blood may lead to heart disease, liver damage, and kidney failure----------------------[nord 2005]----------------

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External Links Related to Sideroblastic Anemia Siderochrestic
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Wikipedia
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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