Disease Information for Sennetsu fever/Ehrlichiosis variant

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Clinical Manifestations
Signs & Symptoms
Anorexia Decreased appetite
Nausea
Vomiting
Tender lymph nodes/systemic
Muscle Pain
Myalgias
Tender or painful muscles/Myalgias
Headache
Acutely ill patient/signs
Constitutional symptoms
Fatigue Tiredness in Children
Fever
Fever Febrile Possible
Fever in kids
Flu-Like Syndrome
High body temperature
Disease Progression
Course/Acute
Course/Continued/persistent symptoms occur
Course/Five week illness
Onset/Acute
Demographics & Risk Factors
Exposure Factors
Exposure/Raw fish ingestion
Exposure/Tick bite
Travel, Geographic & Climate Related Factors
Residence/travel/Oklahoma
Residence/travel/Southeastern USA
Residence/travel/Texas
Laboratory Tests
Microbiology & Serology Findings
Microlab/Ehrlichia sennetsu isolation
Abnormal Lab Findings (Non Measured)
Acute inflammatory markers elevated (Lab)
Hepatic Enzymes Abnormal (Lab)
Leukopenia
Liver Functions Abnormal (Lab)
Transaminase elevation (Lab)
Abnormal Lab Findings - Decreased
WBC
WBC/White Blood Cell Count/Leukocytes (Lab)
Associated Diseases & Rule outs
Rule Outs
Acute viremia
Babesiosis
Insect Bites
Associated Disease & Complications
Ehrlichiosis/Granulocytic Ehrlichiosis
Disease Mechanism & Classification
Specific Agent
AGENT/Anaerobes/unusual bacteria (category)
AGENT/Bacteria (category)
AGENT/Tick-borne illness (ex)
Process
PROCESS/INCIDENCE/Rare disease (ex)
PROCESS/Infection/agent specific (category)
Treatment
Drug Therapy - Contraindication
RX/Doxycycline
RX/Tetracycline (Achromycin)
Definition

Sennetsu Fever; Human Ehrlichial Infection, Sennetsu Type;

Sennetsu Fever is a rare infectious disease belonging to a group of diseases known as the Human Ehrlichioses; These diseases are caused by bacteria belonging to the "Ehrlichia" family; Several forms of Human Ehrlichial infection have been identified including Sennetsu Fever, Human Monocytic Ehrlichiosis (HME), and Human Granulocytic Ehrlichiosis (HGE); Though caused by different strains of Ehrlichia bacteria, the disorders are all characterized by similar symptoms; The symptoms of Sennetsu Fever may include a sudden high fever, headache, and muscle aches (myalgia) within a few weeks after initial infection; In some cases, affected individuals may also experience nausea, vomiting, and/or loss of appetite (anorexia); In addition, in many cases, abnormal laboratory findings may include a decrease in white blood cells (leukopenia) and/or an abnormal increase in the level of certain liver enzymes (hepatic transaminases); Sennetsu Fever is caused by the bacterium Ehrlichia sennetsu; The vector (or carrier) for this bacterium has not yet been determined; however, some researchers believe that infection may result from the ingestion of raw fish;

----------------[NORD Website 2005]--------------

Ehrlichiae are small, gram-negative bacteria that primarily invade leukocytes (white blood cells), the same cells which fight disease by destroying microorganisms that enter the body; Ehrlichiae typically appear as minute, round bacteria (cocci), ranging from 1 to 3 µm (micrometers) in diameter; In the leukocytes, ehrlichiae divide to form vacuole-bound colonies known as morulae (plural for morula, which is the Latin word for mulberry, referring to the mulberry-like clustering of the dividing organisms); The formation of morulae is a defining characteristic of this group of bacterial pathogens; Can be transmitted by tick bites

The ehrlichiae were initially grouped according to the type of blood cell most commonly infected (granulocyte, lymphocyte, monocyte, platelet), and disease classes have been termed "granulocytic (or granulocytotropic) ehrlichiosis" or "monocytic (or monocytotropic) ehrlichiosis." However, this type of classification may be misleading because some of the Ehrlichia species have been found in cells other than their chief target cell type; In addition, more than one species may be responsible for the broad category of "monocytic" or "granulocytic" ehrlichiosis ----------------------[CDC-gov website 2005]--------------

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External Links Related to Sennetsu fever/Ehrlichiosis variant
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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