Disease Information for Semustine (Methyl-CCNU) Administration/Toxicity

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Associated Diseases & Rule outs
Associated Disease & Complications
Fetal anomaly
Disease Mechanism & Classification
Drugs
DRUG/Alkylating agents (example)
DRUG/Chemotherapeutics/cancer drugs/etc (category)
DRUG/Nitrosurea alkylating agents (example)
DRUG/Readily enters CNS/CSF Blood-brain barrier
DRUG/Teratogenic potential/effect (D plus )
Process
PROCESS/Medication/Drug (CONFIRM dose/before treatment)
Synonyms
Synonym
1 (2 Chloroethyl) 3 (4 methylcyclohexyl) 1 nitrosourea, 1 (2 Chloroethyl) 3 (Trans 4 Methylcyclohexane) 1 Nitrosourea, CCNU methyl, Lomustine Methyl, MCCNU, Me CCNU, MeCCNU, Methyl CCNU, Methyl lomustine, Methyl lomustine (substance), Semustine, trans Methyl CCNU, Urea 1 (2 chloroethyl) 3 (4 methylcyclohexyl) 1 nitroso trans (8CI), Urea N (2 chloroethyl) N' (4 methylcyclohexyl) N nitroso, urea N (2 chloroethyl) N' (4 methylcyclohexyl) N nitroso trans (9CI), Brand name/Methyl-CCNU (Semustine)
Definition

Cancer chemotherapy use NitrosUrea Alkylating agent; used primarily for CNS lesions.

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External Links Related to Semustine (Methyl-CCNU) Administration/Toxicity
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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