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Disease Information for Scleroderma renal disease

Clinical Manifestations
Signs & Symptoms: Accentuated A2 sound/cardiac; Diastolic hypertension; High blood pressure/sign
: Nocturia
Clinical Presentation & Variations: Presentation/Hypertension Abrupt Onset
Disease Progression: Course/Chronic disorder; Course/Chronic only
Demographics & Risk Factors
Established Disease Population: Patient/Scleroderma
Laboratory Tests
Abnormal Lab Findings (Non Measured): Renal function abnormalities (Lab)
: URINE Sediment/Urinalysis abnormal
Abnormal Lab Findings - Decreased: Potassium, serum (Lab)
Abnormal Lab Findings - Increased: Anti-SCL-70 (antinucleotide) (Lab)
: BUN/Blood urea nitrogen (Lab); Creatinine, serum (Lab); Plasma renin Activity/PRA (Lab); Renin, serum (Lab); Scleroderma Antibodies (SCL-70); Uric acid, serum (Lab)
: URINE Protein (Albumin)
Diagnostic Test Results
Pathology: BX/Renal Abnormal
Isotope Scan: Isotope/Gallium scan/Bilateral increased renal pick-up
CT Scan: CT Scan/Renal/No contrast/Small kidneys
X-RAY: Xray/Small kidneys/KUB
X-RAY With contrast: IVP/Small kidneys bilateral
Ultrasound: Ultrasound/Renal Small kidneys/bilateral
Associated Diseases & Rule outs
Rule Outs: Hemolytic-uremic syndrome
Associated Disease & Complications: Acute Renal Failure; Azotemia/Acute; Encephalopathy, hypertensive; Hyperaldosteronism, secondary; Hypertension; Hypertensive heart disease; Hypertensive retinopathy, acute; Hyperuricemia; Hypokalemia; Intracerebral hematoma; Microangiopathic anemia/disease; Proteinuria; Pyelonephritis, acute; Renal Failure Chronic; Renal hypertension; Scleroderma renal disease
: Proteinuria in Elderly
: Ischemic Retinopathy
Disease Mechanism & Classification
Class: CLASS/Dermatologic/Subcutaneous (category)
: CLASS/Primary renal disease (ex); CLASS/Renal/kidney involvement/disorder (ex); CLASS/Urologic (category)
Pathophysiology: Pathophysiology/Mechanical Hemolysis
: Pathophysiology/Renal manifestations/involvement; Pathophysiology/Secondary Renal Failure
Process: PROCESS/Allergy/collagen/autoimmune (category); PROCESS/Collagen disease (ex); PROCESS/Complicating disorder (ex); PROCESS/Complicating/Specific process disorder (ex)
Treatment
Drug Therapy - Indication: RX/ACE inhibitor
Definition: Be the first to add a definition for Scleroderma renal disease
External Links Related to Scleroderma renal disease: Google; Wikipedia; Merck; Images; PubMed (National Library of Medicine); NGC (National Guideline Clearinghouse); Medscape (eMedicine); Harrison's Online (accessmedicine); NEJM (The New England Journal of Medicine)

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