Disease Information for Schmidt's syndrome/Polyglandular autoimmune dis II

Clinical Manifestations
Signs & Symptoms
Dizzy on Standing/Giddy Response
Low Blood Pressure
Orthostatic drop in blood pressure
Increased pigmentation/tanning/hyperpigmented
Weak/Weak as a kitten (symptom)
Amenorrhea, primary
Chronic Low Body Temperature
Chronically ill patient/signs
Enervated/extreme acute fatigue
Weakness non-neuromuscular/systemic
Weakness/wooziness/standing quickly
Clinical Presentation & Variations
Presentation/Addisons Myxedema Diabetes Mellitus
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Young Adult
Sex & Age Groups
Population/Adult Aged Only
Population/Woman patient
Population/Young adult
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Differential blood smear/morphology abnormal
Abnormal Lab Findings - Decreased
Cortisol (Lab)
Estrogen, serum (Lab)
Free T4 (Lab)
FTI/Free Thyroxin Index (Lab)
Sodium, serum (Lab)
Thyroxin/T4 (Lab)
Tri-iodothyronine/T3 as Resin Uptake (Lab)
Abnormal Lab Findings - Increased
Anti-parietal cell antibody (Lab)
Cholesterol (Lab)
FSH/Follicle Stmulating Hormone/ICSH (Lab)
TSH/Thyroid stimulating hormone (Lab)
Diagnostic Test Results
Other Tests & Procedures
TEST/Glucose tolerance test/reactive hypoglycemia
Isotope Scan
Isotope/Thyroid Scan Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Addison's disease
Diabetes mellitus
Gonadotropin deficiency/Female acquired
Hypogonadism, male
Hypoparathyroidism, primary
Hypothyroidism (myxedema)
Infertility/sterility, female
Orthostatic hypotension syndrome
Pernicious anemia
Polyglandular autoimmune syndrome
Schmidt syndrome
Secondary female hypogonadism
Thyroiditis, Hashimoto's
Autoimmune Addison's Disease
Diabetes mellitus/non-insulin dep/type II
Disease Mechanism & Classification
CLASS/Adrenal gland disorders (ex).
CLASS/Endocrine gland (category)
CLASS/Thyroid gland disorder (ex)
CLASS/Endometrium involvement/disorder (ex)
Pathophysiology/Gene locus 21q22.3
Pathophysiology/Gene locus chromosome 21
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Secondary Testicular Failure
Pathophysiology/Maternal Chromosome mutation
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Autoimmune disorder (ex)
PROCESS/Endocrine/humoral disorders (category)
PROCESS/Eponymic (category)
PROCESS/Genetic disorder/Spontaneous mutations/sporadic
PROCESS/Vegetative-Autonomic/Endocrine (category)
Addison's disease toxic diffuse goiter and insulin dependent diabetes mellitus, Addison's disease toxic diffuse goitre AND insulin dependent diabetes mellitus, Addison's disease with struma lymphomatosa, APS II, APS type 2, APS2, AUTOIMMUNE POLYENDOCRINE SYNDROME TYPE II, Autoimmune Polyglandular Syndrome Type II, Autoimmune Syndrome Type II Polyglandular, Diab mell Add dis myxoed, DIABETES MELLITUS ADDISON DISEASE MYXEDEMA, Diabetes mellitus Addison's disease and myxedema, Diabetes mellitus Addison's disease and myxoedema, PGA Polyglandular autoimmune syndrome type II, PGA II, POLYENDOCRINE AUTOIMMUNE SYNDROME TYPE II, Polygland autoimm syn typeII, Polyglandular autoimmune syndrome type II, Polyglandular autoimmune syndrome type 2, Polyglandular autoimmune syndrome type 2 (disorder), POLYGLANDULAR AUTOIMMUNE SYNDROME TYPE II, Polyglandular Type II Autoimmune Syndrome, Primary hypothyroidism and adrenocortical insufficiency, Schmidt, SCHMIDT SYNDROME, Schmidts Syndrome, Schmidt's syndrome, Syndrome Schmidt's, Type 2 polyendoc autoimmun syn, Type 2 polyendocrine autoimmunity syndrome, Synonym/Diabetes mellitus,Addisons disease, myxedema, Synonym/Multiple endocrine deficiency syndrome, type II, Synonym/PGA II, Synonym/Pluriglandular insufficiency syndrome, Synonym/Polyglandular autoimmune syndrome, type II, Synonym/Polyglandular deficiency syndrome, type II, Synonym/Thyroid-adrenocortical insufficiency syndr.

Autoimmune polyglandular syndrome type I is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis; Malabsorption and diarrhea can be very striking and even dominate the clinical picture--------------- Schmidt"s syndrome is PGA type II; Neufeld class 1,2,3: recognized 3 types of the polyglandular autoimmune syndrome; All with autoimmune Addison disease as part of a polyglandular autoimmune syndrome; PGA I is represented by patients who have at least 2 of the triad of Addison disease, hypoparathyroidism, and chronic mucocutaneous candidiasis; Associated immune disorders may be present; The Addison disease of PGA I has its predominant age of onset in childhood or early adulthood; It is also frequently associated with chronic active hepatitis, malabsorption, juvenile-onset pernicious anemia, alopecia, and primary hypogonadism; Insulin-dependent diabetes mellitus and/or autoimmune thyroid disease are infrequent;

PGA II (Schmidt syndrome) is represented by patients who have Addison disease with autoimmune thyroid disease and/or insulin-dependent diabetes mellitus, but do not have hypoparathyroidism or candidiasis, although other autoimmune disorders may be present; PGA II is predominantly a disease of middle-aged females;

The autoimmune disorders that occur with PGA I (eg, chronic active hepatitis) are rare in PGA II, except for a low frequency of gonadal failure; Addison disease probably has a different genetic basis in PGA I than in PGA II


External Links Related to Schmidt's syndrome/Polyglandular autoimmune dis II
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)