Disease Information for Schmidt's syndrome/Polyglandular autoimmune dis II

Autoimmune polyglandular syndrome type I is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis; Malabsorption and diarrhea can be very striking and even dominate the clinical picture--------------- Schmidt"s syndrome is PGA type II; Neufeld class 1,2,3: recognized 3 types of the polyglandular autoimmune syndrome; All with autoimmune Addison disease as part of a polyglandular autoimmune syndrome; PGA I is represented by patients who have at least 2 of the triad of Addison disease, hypoparathyroidism, and chronic mucocutaneous candidiasis; Associated immune disorders may be present; The Addison disease of PGA I has its predominant age of onset in childhood or early adulthood; It is also frequently associated with chronic active hepatitis, malabsorption, juvenile-onset pernicious anemia, alopecia, and primary hypogonadism; Insulin-dependent diabetes mellitus and/or autoimmune thyroid disease are infrequent;

PGA II (Schmidt syndrome) is represented by patients who have Addison disease with autoimmune thyroid disease and/or insulin-dependent diabetes mellitus, but do not have hypoparathyroidism or candidiasis, although other autoimmune disorders may be present; PGA II is predominantly a disease of middle-aged females;

The autoimmune disorders that occur with PGA I (eg, chronic active hepatitis) are rare in PGA II, except for a low frequency of gonadal failure; Addison disease probably has a different genetic basis in PGA I than in PGA II

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