Disease Information for Ricin injection/deliberate poisoning

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Clinical Manifestations
Signs & Symptoms
Low Blood Pressure
Signs of Poor Perfusion
Bruising/Ecchymosis
Dependent purpura/sign
Acute spontaneous/widespread bleeding/signs
Bleeding from all orifices
Excessive/easy bruising tendency
Abdominal Pain
Acute abdomen
Bloody diarrhea
Diarrhea
Gastric symptoms/signs
Nausea
Stool color/appearance abnormal
Vomiting
Bleeding from mouth/oral blood
Bleeding gums
Drowsiness/somnolence
Seizures
Stupor/poor reponse to stimulus
Hemoptysis
Hematuria, gross
Oliguria/Decreased urine output
Acutely ill patient/signs
Collapse/Prostration
Bleeding from eyes
Clinical Presentation & Variations
Presentation/Eye Oral GI GU Hemorrhage
Presentation/Intentional poisoning Healthy person
Disease Progression
Course/Acute
Course/Acute only
Course/Catastrophic presentation/onset
Course/Fulminant/Precipitous
Course/Lethal
Course/Poisoning like onset/Abrupt severe
Course/Relentless
Demographics & Risk Factors
Exposure Factors
Exposure/Massive sudden population illness/death agent
Exposure/Terrorist Chemical weapon agent
Exposure/Terrorist/Chemical-biological weapon (CBW)
Event, Activity, Behavioral & Seasonal Factors
Event/Mass exposure/community illness/death
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Triangular fragmented forms RBC/Smear
Bite cells/RBC (Lab)
Blister cells/RBC (Lab)
Microangiopathic blood smear (Lab)
Renal function abnormalities (Lab)
Rouleaux RBC pattern/blood smear (Lab)
Schizocytes on smear (Lab)
URINE Dipstick /Blood abnormal
Abnormal Lab Findings - Decreased
Platelet count (Lab)
Abnormal Lab Findings - Increased
Rouleaux formation (Lab)
URINE Casts/Protein casts
URINE Hemoglobin
URINE Hyaline Casts
URINE Protein (Albumin)
URINE Red blood cells
STOOL Erythrocytes/RBCs
Diagnostic Test Results
Pathology
PATH/Capillaritis/thrombosis
Associated Diseases & Rule outs
Associated Disease & Complications
Acute Renal Failure
Acute Tubulointerstitial Nephropathy
Azotemia/Acute
Bleeding diathesis/hemorrhagic diathesis
Bleeding Tendency
Chemical cystitis
Convulsions (grand mal)
Death/Unanticipated
Disseminated intravascular coagulation
Epistaxis/nosebleed
Gastrointestinal bleeding
Hallucinations
Hemoglobinuria
Hemolysis anemia/acute/active
Hypotension
Nephritis tubulointerstitial
Proteinuria
Ricin poisoning
Sedation/torpor induced
Shock
Thrombocytopenia
Hematuria
Multiple organ System Failure
Disease Mechanism & Classification
Drugs
DRUG/Lowers seizure threshold
Pathophysiology
Pathophysiology/Hemolytic process/effect
Pathophysiology/Intravasular coagulation process
Pathophysiology/Spontaneous Coagulation
Toxin
TOXIN/CBRNE (Chemical/Biologic Weapons All) potential
TOXIN/CBW Biologic poison/non-living (ex)
TOXIN/Lethal often
TOXIN/Plant Circulatory collapse toxin
TOXIN/Plant CNS depressant poisoning
TOXIN/Plant VERY TOXIC/DEADLY tiny doses
TOXIN/Poison Organic (category)
TOXIN/Poison/Botanical/alkaloids/plant toxins (category)
TOXIN/Poisonous Plant (ex)
TOXIN/RNA degraded all cells/apoptosis
TOXIN/Toxin/Heat labile (ex)
TOXIN/Weapon/anti-personnel agent/poison (ex)
Treatment
Drug Therapy - Indication
RX/Antitoxin/antivenom
RX/Ricin Antitoxin
Other Treatments
TX/Platelet transfusion
Definition

Toxin. Ricin is derived from castor beans. Highly toxic purgative cathartic ingested and toxic gastroenetritis with shock. Also causes lethal effect in small doses inhaled. Fever, cough, shortness of breath, chest tightness, hypotension within eight hour, death in 24-72 hours. mass exposure community high incidence. When injected causes intravascular disseminated coagulation (DIC) and acute renal

shut down shock, fever, death.

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External Links Related to Ricin injection/deliberate poisoning
Google
Wikipedia
Merck
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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