Disease Information for Retinoblastoma

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Clinical Manifestations
Signs & Symptoms
Anisocoria
Blindness/unilateral
Chronic Vision Loss, Persistent
Decreasing visual acuity
Decreasing visual acuity in Children
Difficulty Focusing Eyes
Diplopia Double vision
Eye Pain, Unilateral
Eye Pains, Bilateral
Eye symptoms/signs
Leukocoria White pupil reflex
Ophthalmoscopic/Fundoscopic exam/abnormal
Pupil Abnormal/Signs
Retinal hemorrhages/sign
Retinal lesions
Unequal pupils
Vision Loss
Visual Problems
Visual symptoms
White light reflex/eye unilateral
Disease Progression
Course/Chronic disorder
Course/Chronic only
Demographics & Risk Factors
Population Group
Child
Population/Pediatrics population
Sex & Age Groups
Population/Child
Population/Children/all
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Chromosomal abnormality (Lab)
Abnormal Lab Findings - Increased
Alpha Fetoprotein, serum (Lab)
Dopamine (Lab)
Diagnostic Test Results
Other Tests & Procedures
Intraocular Pressure increased
Ocular tonometry abnormal
X-RAY
Xray/Intraorbital calcifications/Head
Xray/Orbital lesion/Head
Associated Diseases & Rule outs
Rule Outs
Congenital cataracts
Diabetic retinopathy
Optic neuritis
Retrolental fibroplasia
Associated Disease & Complications
Blindness
Blindness in Children
Brain tumor
Cancer in Children
Childhood malignancy
Craniofacial osteogenic sarcoma
Glaucoma
Glaucoma, secondary
Optic neuritis
Primary Brain Neoplasm
Retinal hemorrhage
Retinoblastoma
Strabismus
Visual acuity loss
Intraocular Neoplasm
Disease Mechanism & Classification
Class
CLASS/Eye involvement/disorder (ex)
CLASS/Eyes/accessory (category)
CLASS/Retina involvement/disorder (ex)
Pathophysiology
Pathophysiology/Gene locus 13q14.1-q14.2
Pathophysiology/Gene locus Chromosome 13
Pathophysiology/Gene locus chromosome 13q
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Gene mutation loss anti-oncogene loci
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
Pathophysiology/Oncogene RB1/Locus 13q
Pathophysiology/Oncogene VHL/Locus 3p
Pathophysiology/Radioresistant malignancy/relative
Process
PROCESS/Chemotherapy responsive cancer (ex)
PROCESS/Hereditary/Genetic predisposition (ex)
PROCESS/Hereditofamilial (category)
PROCESS/Malignancy in childhood (ex)
PROCESS/Malignancy/cancer (ex)
PROCESS/Neoplastic (category)
PROCESS/Eye tumor (ex)
Treatment
Drug Therapy - Indication
RX/Chemotherapy(cancer)
RX/Cis-Retinoic acid (Isotretinoine)
SX/Enucleation/eye
SX/Eye Surgery
Surgical Procedures or Treatments
SX/Surgery
Definition

An eye cancer that most often occurs in children younger than 5 years. It occurs in hereditary and nonhereditary (sporadic) forms.

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External Links Related to Retinoblastoma
Google
Wikipedia
Merck
Images
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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