Disease Information for Restless legs syndrome

Clinical Manifestations
Signs & Symptoms
Bilateral Calf Pains
Leg cramps,nocturnal
Leg cramps/muscle spasm/pains
Leg Pain
Restless legs
Daytime Sleepiness
Insomnia, PM type
Nocturnal Myoclonus
AM/exhaustion,non-refreshing sleep
Hypersomnia/Increased need for sleep
Nocturnal awakenings Events Phenomenon
Disease Progression
Course/Benign course/disorder
Course/Self limited usually
Demographics & Risk Factors
Established Disease Population
Patient/Uremia/Chronic renal disease
Sex & Age Groups
Population/Middle-aged adult
Diagnostic Test Results
Other Tests & Procedures
Test/Sleep Study Abnormal
Associated Diseases & Rule outs
Associated Disease & Complications
Restless legs syndrome
Sleep deprivation
Sleep Fragmentation
Disease Synergy - Causes
Synergy/Sleep deprivation
Disease Mechanism & Classification
CLASS/Extremities/Digits/Hand feet disorder (category)
CLASS/Neurologic (category)
Pathophysiology/Gene locus 12q12-q21
Pathophysiology/Gene locus chromosome 12
Pathophysiology/Gene locus chromosome 12q
Pathophysiology/Gene Locus Identified/OMIM database
Pathophysiology/Genomic indentifiers (polymorphism/snip/mutations)
PROCESS/Vegetative-Autonomic/Endocrine (category)
Ekbom, ekbom syndrome, Ekboms Syndrome, Ekbom's Syndrome, LEGS RESTLESS, RESTLESS LEG SYNDROME, RESTLESS LEGS, Restless legs (disorder), Restless legs syndrome, Restless legs syndrome (RLS), Syndrome Ekbom, Syndrome Ekbom's, SYNDROME RESTLESS LEGS, Synonym/Anxietas tibialis, Synonym/Ekbom's syndrome (Restless legs), Synonym/Idiopathic torsion dystonia, Synonym/Wittmaack-Ekbom syndrome
Drug Therapy - Indication
RX/Antihistamine medication
RX/Bromocriptine (Parlodel)
RX/Carbamazepine (Tegretol)
RX/Carbidopa (Lodosyn)
RX/Carbidopa-Levodopa (Sinemet)
RX/Clonidine (Catapres)
RX/Diphenhydramine (Benadryl)
RX/Fluoxetine (Prozac)
RX/Serotonin reuptake inhibitor

A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep; Complying with an irresistible urge to move the affected limbs brings temporary relief; Sleep may become disrupted, resulting in excessive daytime hypersomnolence; This condition may be associated with uremia,diabetes,and rheumatoid arthritis; (Adams et al, Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736); most common with iron deficiency anemia; ----------------------------------Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are two separate but related intrinsic disorders of sleep; RLS is a neurological movement disorder diagnosed strictly by the following four criteria: There is a conscious urge to move the legs (focal akathisia) usually accompanied or caused by uncomfortable or unpleasant sensations in the legs that persist without movement or a counter stimulus; The sensation is described as creepy, crawly, creeping or any other unpleasant adjectives and cannot be ignored; The urge to move or unpleasant sensations begin or worsen when the patient is at rest or inactive (sitting or lying down; The urge or sensation is relieved or reduced by movement but returns

quickly when movement stops; The sensation or urge is worse in the evening or night than during the day or occur only at night or in the evening; PLMD is diagnosed on the basis of the above clinical history plus the recorded evidence of periodic limb movements in sleep (PLMS); There are

brief (0.5 to 9 seconds in duration) dystonic leg movements (dorsiflexion of the foot and extension of the great toe); There must be four consecutive movements separated by at least four but not more than 90 seconds to define

an episode


External Links Related to Restless legs syndrome
PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)