Disease Information for Renal thrombotic thrombocytopenic purp.

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Clinical Manifestations
Signs & Symptoms
High blood pressure child
High blood pressure/sign
Osler's nodules/finger-tips/Osler's nodes
Fever
High body temperature
Clinical Presentation & Variations
Presentation/Renal Failure Hemolysis
Laboratory Tests
Abnormal Lab Findings (Non Measured)
Triangular fragmented forms RBC/Smear
Serum ADAM-TS13 Inhibitor Present
Acanthocytes peripheral smear (Lab)
Bite cells/RBC (Lab)
Blister cells/RBC (Lab)
Microangiopathic blood smear (Lab)
Normocytic anemia
Normocytic/Normochromic Anemia (Lab)
Renal function abnormalities (Lab)
Schizocytes on smear (Lab)
URINE Sediment/Urinalysis abnormal
Abnormal Lab Findings - Decreased
Serum ADAM-TS13
Hematocrit (Lab)
Hemoglobin (Lab)
Platelet count (Lab)
RBC/Red Blood Count (Lab)
Abnormal Lab Findings - Increased
BUN/Blood urea nitrogen (Lab)
Creatinine, serum (Lab)
Lactic Dehydrogenase (LDH LH) (Lab)
URINE Hemoglobin
URINE Red blood cells
Diagnostic Test Results
Pathology
BX/Renal Abnormal
Associated Diseases & Rule outs
Rule Outs
HELLP syndrome of pregnancy
Hemolytic anemia/autoimmune
Hemolytic-uremic syndrome
Associated Disease & Complications
Acanthocytosis
Acute anuria/renal failure
Acute Renal Failure
Anemia
Azotemia in Elderly
Azotemia/Acute
Hemoglobinuria
Hemolysis anemia/acute/active
Hypertension in a child
Microangiopathic anemia/disease
Renal Failure Chronic
Thrombocytopenia
Hematuria
Disease Mechanism & Classification
Class
CLASS/Hematologic (category)
CLASS/Platelet disorder (ex)
CLASS/Urologic (category)
Pathophysiology
Pathophysiology/Antibody to ADAM-TS13V Factor
Pathophysiology/Hemolysis
Pathophysiology/Mechanical Hemolysis
Process
PROCESS/Allergy/collagen/autoimmune (category)
PROCESS/Complicating disorder (ex)
PROCESS/Reference organ/system (category)
PROCESS/Coagulation derangement/disorder (ex)
Treatment
Other Treatments
TX/Plasmapheresis/exchange.
Definition

thrombotic thrombocytopenia purpura; Microangiopathic Hemolytic Anemia; Moschowitz Disease; TTP; Thrombotic thrombocytopenia purpura (TTP) is a rare, serious blood disease; Major symptoms may include a severe decrease in the number of blood platelets (thrombocytopenia), abnormal destruction of red blood cells (hemolytic anemia), and disturbances in the nervous system; Kidney dysfunction and fever are also common; The exact cause of thrombotic thrombocytopenic purpura is unknown;

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Some caes triggered by E coli O157:H7

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening multisystem disorder that is considered a true medical emergency; Moschcowitz first described TTP in 1924 when he noted that his 16 year-old patient had anemia; petechiae; microscopic hematuria; and at autopsy, disseminated microvascular thrombi; Since that time, the pathophysiology, etiology, and medical management of TTP has expanded; This life-threatening condition may have positive outcomes if recognized early and if medical intervention is initiated early; Thrombocytopenic purpura is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction; With the introduction of plasma exchange, the survival rate has improved from approximately 3% prior to the 1960s to 82%; Early plasma exchange initiation has beneficial outcomes;

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External Links Related to Renal thrombotic thrombocytopenic purp.
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PubMed (National Library of Medicine)
NGC (National Guideline Clearinghouse)
Medscape (eMedicine)
Harrison's Online (accessmedicine)
NEJM (The New England Journal of Medicine)
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