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Disease Information for Quetiapine (Seroquel) Administration/Toxicity

Clinical Manifestations

Signs & Symptoms

Dizzy on Standing/Giddy Response

Orthostatic drop in blood pressure

Dry mouth/Mucous membranes

Motor restlessness

Akathisia

Athetosis

Choreoathetoid movement

Dystonia, acquired

Odd body posturing

Seizures

Stupor/poor reponse to stimulus

Tremor

Unable to sit still/restlessness

Diagnostic Test Results

EKG (ECG)

EKG/Drug induced QT prolongation (ECG)

Associated Diseases & Rule outs

Associated Disease & Complications

Cardiac arrhythmias

Cataract

Convulsions (grand mal)

Drug induced Acute dystonia reaction

Drug Induced Choreoathetosis

Drug induced Movement disorder

Drug induced Orthostatic hypotension

Neuroleptic malignant syndrome

Orthostatic hypotension syndrome

Orthostatic syncope Hypotension

Sedation/torpor induced

Tardive dyskinesia syndrome

Urinary bladder retention

Disease Mechanism & Classification

Drugs

DRUG/Antipsychotic/neuroleptic drug (example)

DRUG/Anti-Schizophrenia medication (example)

DRUG/Atypical anti-psychotic neuroleptic drugs

DRUG/Phenothiazine class drug (example)

DRUG/Psychoactive/sedative drug (category)

DRUG/Blocks Serotonin/Dopamine receptors

DRUG/Lowers seizure threshold

Process

PROCESS/Medication/Drug (CONFIRM dose/before treatment)

Synonyms

Synonym

admin, Quetiapine (Seroquel), Brand name/Seroquel (Quetiapine)

Treatment

Drug Dosage

DRUG/.$$$$$ Most Expensive

DRUG/Dose 100 mgm (Unit/Pill/Capsule size)

DRUG/Dose 25 mgm (Unit/Pill/Capsule size)

DRUG/Dose BID Medication

DRUG/Dose must be titrated to effect

DRUG/Dose TID Medication

DRUG/Oral medication (ex)

Definition

Thorazine-like drug; class of neuroleptic drugs for anti-psychosis effect; oral and parenteral drug; causes sedation, tardive dyskinesia; basal ganglia effects; wide margin of safety

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External Links Related to Quetiapine (Seroquel) Administration/Toxicity

PubMed (National Library of Medicine)

NGC (National Guideline Clearinghouse)

Medscape (eMedicine)

Harrison's Online (accessmedicine)

NEJM (The New England Journal of Medicine)

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